Polymeric microactuators for responsive drug delivery systems

Leonidas G Bachas, Elizabeth A. Moschou, Han Kuan Tsai, Jim Zoval, Marc J. Madou, Sylvia Daunert

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of novel polymeric actuators with fast, reproducible, and reversible actuation at physiological pH environments under low power requirements is of great importance nowadays. Such systems can find a wide range of applications, including the development of bio-micro-electromechanical systems (BioMEMS) for biological and medical applications. In this presentation we will discuss the development of polymeric micro- and nanoscale actuators based on two different strategies. First, polymeric actuators composed of the electroactive polymer polypyrrole (PPy) deposited on top of gold layers have been microfabricated. These actuators are made in the shape of micro and nanoscale flaps fixed on top of microvials. Under electroactuation the polymeric actuators bend, acting as microvalves, and opening the top of the reservoirs. These microactuators are able to electroactuate with a fast response time at neutral pH environments under low power requirements. On another approach, an electroactive polymeric actuator based on acrylic acid, acrylamide and PPy/carbon black composite has been developed. This polymeric actuator acts as an artificial muscle, bending on demand under the application of low voltage with a fast response time. The biocompatibility, low power requirements and ability for fast electroactuation at neutral pH environments make both polymeric actuator systems suitable for numerous biological and medical applications, including the development of responsive drug delivery systems.

Original languageEnglish
Title of host publicationAIChE Annual Meeting, Conference Proceedings
StatePublished - Dec 1 2005
Externally publishedYes
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

Fingerprint

Microactuators
Actuators
Polypyrroles
Medical applications
Flaps
Drug Delivery Systems
Polymers
Carbon black
Biocompatibility
Acrylics
MEMS
Muscle
Gold
Acids
Composite materials
Electric potential

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Bachas, L. G., Moschou, E. A., Tsai, H. K., Zoval, J., Madou, M. J., & Daunert, S. (2005). Polymeric microactuators for responsive drug delivery systems. In AIChE Annual Meeting, Conference Proceedings

Polymeric microactuators for responsive drug delivery systems. / Bachas, Leonidas G; Moschou, Elizabeth A.; Tsai, Han Kuan; Zoval, Jim; Madou, Marc J.; Daunert, Sylvia.

AIChE Annual Meeting, Conference Proceedings. 2005.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bachas, LG, Moschou, EA, Tsai, HK, Zoval, J, Madou, MJ & Daunert, S 2005, Polymeric microactuators for responsive drug delivery systems. in AIChE Annual Meeting, Conference Proceedings. 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States, 10/30/05.
Bachas LG, Moschou EA, Tsai HK, Zoval J, Madou MJ, Daunert S. Polymeric microactuators for responsive drug delivery systems. In AIChE Annual Meeting, Conference Proceedings. 2005
Bachas, Leonidas G ; Moschou, Elizabeth A. ; Tsai, Han Kuan ; Zoval, Jim ; Madou, Marc J. ; Daunert, Sylvia. / Polymeric microactuators for responsive drug delivery systems. AIChE Annual Meeting, Conference Proceedings. 2005.
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