Polymeric biomaterials with degradation sites for proteases involved in cell migration

Jennifer L. West, Jeffrey A. Hubbell

Research output: Contribution to journalArticlepeer-review

481 Scopus citations

Abstract

A new class of biodegradable polymeric biomaterials is described which exhibits degradation by specific enzymes that are localized near cell surfaces during cell migration. These materials are telechelic BAB block copolymers of the water-soluble biocompatible polymer, polyethylene glycol (A block) and short oligopeptide that are cleavage sequences for targeted enzymes (B block). These polymers are further capped at each end with reactive acrylate groups to allow polymerization to form crosslinked hydrogel networks. The combination of two types of bioactive signals, one for cell-mediated degradation, and one for cell adhesion, into one material should achieve a biomemitic polymeric hydrogel with properties of natural extracellular matrix.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalMacromolecules
Volume32
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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