Polymer stent coating for prevention of neointimal hyperplasia

Michael Billinger, Felix Buddeberg, Jeffrey A. Hubbell, Donald L. Elbert, Thomas Schaffner, Daniel Mettler, Stephan Windecker, Bernhard Meier, Otto M. Hess

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

AIMS: Restenosis has been the principal limitation of bare metal stents. Based upon the presumption that platelet and inflammatory cell recruitment initiate neointimal proliferation, we explored a novel polymer coating that reduces cell-stent interactions. The purpose of the present study was to investigate the effect of poly(L-lysine)-graft-poly(ethyleneglycol) (PLL-g-PEG) adsorbed to stent surfaces to reduce neointimal hyperplasia in the porcine restenosis model. METHODS AND RESULTS: Seven animals were instrumented each with 2 stainless steel stents (15 mm length, 2.5 - 3.5 mm diameter), randomly implanted in 1 major epicardial coronary artery. One stent was dip-coated with PLL-g-PEG, whereas the other stent served as the uncoated control stent. All animals were sacrificed after 6 weeks for histological examination. Neointimal hyperplasia was significantly less (-51%) in the PLL-g-PEG-coated stents (1.15 ± 0.59 mm2) than in the uncoated control stents (2.33 ± 1.01 mm2; p < 0.001). Conversely, lumen size was larger in the PLL-g-PEG-coated stents (2.91 ± 1.17 mm2) than in the uncoated stents (2.04 ± 0.64 mm2; p < 0.001). High magnification histomorphologic examination revealed no signs of inflammation or thrombus formation in either stent group. CONCLUSIONS: Polymeric steric stabilization of stents with PLL-g-PEG significantly reduces neointimal hyperplasia in the porcine restenosis model. Reduction of cell-stent interactions mediated by PLL-g-PEG appear to improve biocompatibility of stainless steel stents without evidence of adverse inflammatory or prothrombotic effects.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalJournal of Invasive Cardiology
Volume18
Issue number9
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Billinger, M., Buddeberg, F., Hubbell, J. A., Elbert, D. L., Schaffner, T., Mettler, D., Windecker, S., Meier, B., & Hess, O. M. (2006). Polymer stent coating for prevention of neointimal hyperplasia. Journal of Invasive Cardiology, 18(9), 423-426.