Polyimide-polyethylene glycol block copolymers: Synthesis, characterization, and initial evaluation as a biomaterial

Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Christopher P. Quinn, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Block copolyimides with varying amounts of polyethylene glycol (PEG) were synthesized and characterized by copolymerization of diaminodiphenyl ether (DDE), amino terminated PEG, and ben- zophenone tetracarboxylic acid dianhydride (BTDA). Strong materials were obtained, with enhanced flexibility as compared to the parent DDE-BTDA polyimide homopolymer. Incorporation of PEG led to an increase in water absorption by these copolymers, and hydrophilicity was increased as reflected by a decrease in air-water-polymer contact angle. These materials supported less cell adhesion in vitro than the parent polyimide homopolymer. Short term in vivo evaluation of these copolymers showed reduced fibrous encapsulation than was observed in the absence of PEG.

Original languageEnglish (US)
Pages (from-to)313-323
Number of pages11
JournalJournal of Biomaterials Science, Polymer Edition
Volume6
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Biocompatibility
  • Copolymer
  • Poly(ethylene glycol)
  • Polyimide

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

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