Polyimide-polyethylene glycol block copolymers: synthesis, characterization, and initial evaluation as a biomaterial.

C. P. Pathak, A. S. Sawhney, C. P. Quinn, J. A. Hubbell

Research output: Contribution to journalArticle


Block copolyimides with varying amounts of polyethylene glycol (PEG) were synthesized and characterized by copolymerization of diaminodiphenyl ether (DDE), amino terminated PEG, and benzophenone tetracarboxylic acid dianhydride (BTDA). Strong materials were obtained, with enhanced flexibility as compared to the parent DDE-BTDA polyimide homopolymer. Incorporation of PEG led to an increase in water absorption by these copolymers, and hydrophilicity was increased as reflected by a decrease in air-water-polymer contact angle. These materials supported less cell adhesion in vitro than the parent polyimide homopolymer. Short term in vivo evaluation of these copolymers showed reduced fibrous encapsulation than was observed in the absence of PEG.

Original languageEnglish
Pages (from-to)313-323
Number of pages11
JournalJournal of biomaterials science. Polymer edition
Issue number4
StatePublished - Dec 1 1994
Externally publishedYes


ASJC Scopus subject areas

  • Biophysics

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