Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk

Tasha R. Smith, Edward A. Levine, Rita I. Freimanis, Steven A. Akman, Glenn O. Allen, Kimberly N. Hoang, Wen Liu-Mares, Jennifer Hu

Research output: Contribution to journalArticle

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Abstract

Genetic variations in DNA repair may impact repair functions, DNA damage and breast cancer risk. Using data/samples collected from the first 752 Caucasians and 141 African-Americans in an ongoing case-control study, we examined the association between breast cancer risk and 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways - (i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q and POLD1 R119H; (ii) nucleotide excision repair: ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H and XPC A499V/ K939Q; (iii) mismatch repair: MLH1 I219V, MSH3 R940Q/T1036A and MSH6 G39E and (iv) double-strand break repair: NBS1 E185Q and XRCC3 T241M. In Caucasians, breast cancer risk was significantly associated with ADPRT 762VV [odds ratio (OR) = 1.45; 95% confidence interval (CI) = 1.03, 2.03], APE1 148DD (OR = 1.44; 95% CI = 1.03, 2.00), MLH1 219II/IV (OR = 1.87; 95% CI = 1.11, 3.16) and ERCC4 415QQ (OR = 8.64; 95% CI = 1.04, 72.02) genotypes. With a limited sample size, we did not observe any significant association in African-Americans. However, there were significant trends in breast cancer risk with increasing numbers of risk genotypes for ADPRT 762VV, APE1 148DD, ERCC4 415RQ/QQ and MLH1 219II/IV (Ptrend < 0.001) in Caucasians and ADPRT 762VA, ERCC2 751KQ/QQ and NBS1 185EQ/QQ in African-Americans (Ptrend = 0.006), respectively. Our results suggest that combined nsSNPs in multiple DNA repair pathways may contribute to breast cancer risk and larger studies are warranted to further evaluate polygenic models of DNA repair in breast cancer risk.

Original languageEnglish
Pages (from-to)2132-2138
Number of pages7
JournalCarcinogenesis
Volume29
Issue number11
DOIs
StatePublished - Nov 19 2008

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Genetic Polymorphisms
DNA Repair
ADP Ribose Transferases
Breast Neoplasms
Odds Ratio
African Americans
Confidence Intervals
Single Nucleotide Polymorphism
Genotype
DNA Mismatch Repair
Sample Size
DNA Damage
Case-Control Studies

ASJC Scopus subject areas

  • Cancer Research

Cite this

Smith, T. R., Levine, E. A., Freimanis, R. I., Akman, S. A., Allen, G. O., Hoang, K. N., ... Hu, J. (2008). Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis, 29(11), 2132-2138. https://doi.org/10.1093/carcin/bgn193

Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. / Smith, Tasha R.; Levine, Edward A.; Freimanis, Rita I.; Akman, Steven A.; Allen, Glenn O.; Hoang, Kimberly N.; Liu-Mares, Wen; Hu, Jennifer.

In: Carcinogenesis, Vol. 29, No. 11, 19.11.2008, p. 2132-2138.

Research output: Contribution to journalArticle

Smith, TR, Levine, EA, Freimanis, RI, Akman, SA, Allen, GO, Hoang, KN, Liu-Mares, W & Hu, J 2008, 'Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk', Carcinogenesis, vol. 29, no. 11, pp. 2132-2138. https://doi.org/10.1093/carcin/bgn193
Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN et al. Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis. 2008 Nov 19;29(11):2132-2138. https://doi.org/10.1093/carcin/bgn193
Smith, Tasha R. ; Levine, Edward A. ; Freimanis, Rita I. ; Akman, Steven A. ; Allen, Glenn O. ; Hoang, Kimberly N. ; Liu-Mares, Wen ; Hu, Jennifer. / Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. In: Carcinogenesis. 2008 ; Vol. 29, No. 11. pp. 2132-2138.
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abstract = "Genetic variations in DNA repair may impact repair functions, DNA damage and breast cancer risk. Using data/samples collected from the first 752 Caucasians and 141 African-Americans in an ongoing case-control study, we examined the association between breast cancer risk and 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways - (i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q and POLD1 R119H; (ii) nucleotide excision repair: ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H and XPC A499V/ K939Q; (iii) mismatch repair: MLH1 I219V, MSH3 R940Q/T1036A and MSH6 G39E and (iv) double-strand break repair: NBS1 E185Q and XRCC3 T241M. In Caucasians, breast cancer risk was significantly associated with ADPRT 762VV [odds ratio (OR) = 1.45; 95{\%} confidence interval (CI) = 1.03, 2.03], APE1 148DD (OR = 1.44; 95{\%} CI = 1.03, 2.00), MLH1 219II/IV (OR = 1.87; 95{\%} CI = 1.11, 3.16) and ERCC4 415QQ (OR = 8.64; 95{\%} CI = 1.04, 72.02) genotypes. With a limited sample size, we did not observe any significant association in African-Americans. However, there were significant trends in breast cancer risk with increasing numbers of risk genotypes for ADPRT 762VV, APE1 148DD, ERCC4 415RQ/QQ and MLH1 219II/IV (Ptrend < 0.001) in Caucasians and ADPRT 762VA, ERCC2 751KQ/QQ and NBS1 185EQ/QQ in African-Americans (Ptrend = 0.006), respectively. Our results suggest that combined nsSNPs in multiple DNA repair pathways may contribute to breast cancer risk and larger studies are warranted to further evaluate polygenic models of DNA repair in breast cancer risk.",
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N2 - Genetic variations in DNA repair may impact repair functions, DNA damage and breast cancer risk. Using data/samples collected from the first 752 Caucasians and 141 African-Americans in an ongoing case-control study, we examined the association between breast cancer risk and 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways - (i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q and POLD1 R119H; (ii) nucleotide excision repair: ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H and XPC A499V/ K939Q; (iii) mismatch repair: MLH1 I219V, MSH3 R940Q/T1036A and MSH6 G39E and (iv) double-strand break repair: NBS1 E185Q and XRCC3 T241M. In Caucasians, breast cancer risk was significantly associated with ADPRT 762VV [odds ratio (OR) = 1.45; 95% confidence interval (CI) = 1.03, 2.03], APE1 148DD (OR = 1.44; 95% CI = 1.03, 2.00), MLH1 219II/IV (OR = 1.87; 95% CI = 1.11, 3.16) and ERCC4 415QQ (OR = 8.64; 95% CI = 1.04, 72.02) genotypes. With a limited sample size, we did not observe any significant association in African-Americans. However, there were significant trends in breast cancer risk with increasing numbers of risk genotypes for ADPRT 762VV, APE1 148DD, ERCC4 415RQ/QQ and MLH1 219II/IV (Ptrend < 0.001) in Caucasians and ADPRT 762VA, ERCC2 751KQ/QQ and NBS1 185EQ/QQ in African-Americans (Ptrend = 0.006), respectively. Our results suggest that combined nsSNPs in multiple DNA repair pathways may contribute to breast cancer risk and larger studies are warranted to further evaluate polygenic models of DNA repair in breast cancer risk.

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