Polyethylene wear debris and tissue reactions in knee as compared to hip replacement prostheses

Thomas P. Schmalzried, Murali Jasty, Andrew Rosenberg, William H. Harris

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Polyethylene wear debris and the cellular response in periprosthetic tissues from 19 failed total knee replacements (TKR) was compared to that from 24 failed total hip replacement prostheses (THR) using polarized microscopy and a semiquantitative grading system. The foreign body inflammatory reaction in the THR cases was characterized by plump macrophages with a diffuse cytoplasmic birefringence when examined under polarized light. In TKR cases, the inflammatory reaction was characterized by giant cells with fewer macrophages. The size distribution of the PE wear particles in the two cases were also determined.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalJournal of applied biomaterials
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)

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