Poly(ethylene glycol) based encapsulation of islets of Langerhans

G. M. Cruise, F. V. Lamberti, O. D. Hegre, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new method of encapsulating tissues was developed using photoactivated polyethylene glycol (PEG). Bulk phase and interfacial polymerization techniques were used to encapsulate the islets of Langerhans. The effects of polymerization variables on encapsulation were studied. Among the variables, the concentrations of eosin Y (EY), PEG, and triethanolamine (TEA) were found to be most critical. Data on the percentage of islets showing fibroblast growth indicated the uniformity of the PEG coating and its ability to prevent cellular outgrowth. In addition, PEG was able to prevent cell death via complement for periods up to 3 hours.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Volume1
StatePublished - Dec 1 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Cruise, G. M., Lamberti, F. V., Hegre, O. D., & Hubbell, J. A. (1996). Poly(ethylene glycol) based encapsulation of islets of Langerhans. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1). Soc for Biomaterials.