Polycomb in stem cells: PRC1 branches out

Nuno Miguel Luis, Lluis Morey, Luciano Di Croce, Salvador Aznar Benitah

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalCell Stem Cell
Volume11
Issue number1
DOIs
StatePublished - Jul 6 2012
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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