Polycomb in stem cells: PRC1 branches out

Nuno Miguel Luis, LLuis Morey, Luciano Di Croce, Salvador Aznar Benitah

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalCell Stem Cell
Volume11
Issue number1
DOIs
StatePublished - Jul 6 2012
Externally publishedYes

Fingerprint

Polycomb Repressive Complex 1
Polycomb-Group Proteins
Polycomb Repressive Complex 2
Stem Cells
Adult Stem Cells
Embryonic Stem Cells
Chromatin
Gene Expression

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this

Polycomb in stem cells : PRC1 branches out. / Luis, Nuno Miguel; Morey, LLuis; Di Croce, Luciano; Benitah, Salvador Aznar.

In: Cell Stem Cell, Vol. 11, No. 1, 06.07.2012, p. 16-21.

Research output: Contribution to journalReview article

Luis, NM, Morey, LL, Di Croce, L & Benitah, SA 2012, 'Polycomb in stem cells: PRC1 branches out', Cell Stem Cell, vol. 11, no. 1, pp. 16-21. https://doi.org/10.1016/j.stem.2012.06.005
Luis, Nuno Miguel ; Morey, LLuis ; Di Croce, Luciano ; Benitah, Salvador Aznar. / Polycomb in stem cells : PRC1 branches out. In: Cell Stem Cell. 2012 ; Vol. 11, No. 1. pp. 16-21.
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