Polycomb group protein-mediated repression of transcription

Lluís Morey, Kristian Helin

Research output: Contribution to journalReview article

266 Scopus citations

Abstract

The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

Original languageEnglish (US)
Pages (from-to)323-332
Number of pages10
JournalTrends in Biochemical Sciences
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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