Abstract
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
Original language | English (US) |
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Pages (from-to) | 323-332 |
Number of pages | 10 |
Journal | Trends in Biochemical Sciences |
Volume | 35 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology