Polycomb group protein-mediated repression of transcription

Lluís Morey; Kristian Helin

doi:10.1016/j.tibs.2010.02.009

Polycomb group protein-mediated repression of transcription

Lluís Morey, Kristian Helin

Research output: Contribution to journal › Review article › peer-review

273 Scopus citations

Abstract

The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

Original language	English (US)
Pages (from-to)	323-332
Number of pages	10
Journal	Trends in Biochemical Sciences
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.tibs.2010.02.009
State	Published - Jun 1 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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AB - The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

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JO - Trends in Biochemical Sciences

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Polycomb group protein-mediated repression of transcription

Abstract

ASJC Scopus subject areas

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