Polarizing genetic information in the egg: RNA localization in the frog oocyte

Mary Lou King, Yi Zhou, Mikhail Bubunenko

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned.

Original languageEnglish (US)
Pages (from-to)546-557
Number of pages12
JournalBioEssays
Volume21
Issue number7
DOIs
StatePublished - Jul 1 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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