Polarizing genetic information in the egg: RNA localization in the frog oocyte

Mary Lou L King, Yi Zhou, Mikhail Bubunenko

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned.

Original languageEnglish
Pages (from-to)546-557
Number of pages12
JournalBioEssays
Volume21
Issue number7
DOIs
StatePublished - Jul 1 1999

Fingerprint

Anura
Oocytes
Ovum
frogs
oocytes
RNA
Oogenesis
oogenesis
3' Untranslated Regions
infancy
3' untranslated regions
Germ Cells
Embryonic Development
germ cells
Proteins
embryogenesis
protein synthesis
Cells
cells
proteins

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Polarizing genetic information in the egg : RNA localization in the frog oocyte. / King, Mary Lou L; Zhou, Yi; Bubunenko, Mikhail.

In: BioEssays, Vol. 21, No. 7, 01.07.1999, p. 546-557.

Research output: Contribution to journalArticle

King, Mary Lou L ; Zhou, Yi ; Bubunenko, Mikhail. / Polarizing genetic information in the egg : RNA localization in the frog oocyte. In: BioEssays. 1999 ; Vol. 21, No. 7. pp. 546-557.
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