Pointwise rates of visual field progression cluster according to retinal nerve fiber layer bundles

Kouros Nouri-Mahdavi, Dennis Mock, Hamid Hosseini, Elena Bitrian, Fei Yu, Abdelmonem Afifi, Anne L. Coleman, Joseph Caprioli

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


PURPOSE. To explore whether pointwise rates of visual field progression group together in patterns consistent with retinal nerve fiber layer (RNFL) bundles. METHODS. Three hundred eighty-nine eyes of 309 patients from the Advanced Glaucoma Intervention Study with ≥ 6 years of follow-up and ≥12 reliable visual field exams were selected. Linear and exponential regression models were used to estimate pointwise rates of change over time. Clustering of pointwise rates of progression was investigated with hierarchical cluster analysis using Pearson's correlation coefficients as distance measure and an average linkage scheme for building the hierarchy with cutoff value of r > 0.7. RESULTS. The average mean deviation (±SD) was -10.9 (±5.4). The average (±SD) follow-up time and number of visual field exams were 8.1 (±1.1) years and 15.7 (±3.0), respectively. Pointwise rates of progression across the visual field grouped into clusters consistent with anatomic patterns of RNFL bundles with both linear (10 clusters) and exponential (six clusters) regression models. One hundred forty-four (37%) eyes progressed according to the two-omitting pointwise linear regression model. CONCLUSIONS. Pointwise rates of change in glaucoma patients cluster into regions consistent with RNFL bundle patterns. This finding validates the clinical significance of such pointwise rates. The correlations among pointwise rates of change can be used for spatial filtering purposes, facilitating detection or prediction of glaucoma progression.

Original languageEnglish (US)
Pages (from-to)2390-2394
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - Apr 2012
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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