Podocytopathy in diabetes: A metabolic disorder

Research output: Contribution to journalArticle

Abstract

Background: Despite multifactorial interventions, the prevalence of diabetic kidney disease (DKD) is reaching epidemic proportions worldwide. Loss of podocytes, the cells forming the glomerular filtration barrier, occurs early in the development of DKD and is associated with the presence of albuminuria.

Summary: Recent studies have implicated circulating hormones, adipokines and lipids in the development and progression of DKD.

Key Message: Although the endocrine effects of these factors are widely recognized, less is known about their direct effects on podocytes and the resulting implications for DKD.

Original languageEnglish
Pages (from-to)157-173
Number of pages17
JournalContributions to Nephrology
Volume183
DOIs
StatePublished - Jan 1 2014

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