Pneumocystis jirovecii pneumonia as a complication of etoposide therapy

Maria Alejandra Mendoza; Sunil Iyer; Jose F. Camargo; Pasquale W. Benedetto

doi:10.1136/bcr-2021-242485

Pneumocystis jirovecii pneumonia as a complication of etoposide therapy

Maria Alejandra Mendoza, Sunil Iyer, Jose F. Camargo, Pasquale W. Benedetto

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Two patients receiving oral etoposide therapy developed Pneumocystis jirovecii pneumonia during chemotherapy with significant lymphopenia without corticosteroid use. In this commentary we discuss cellular mechanisms by which etoposide induced CD4+ T lymphocyte dysfunction and reduced survival may lead to predisposition to P. jirovecii infection.

Original language	English (US)
Article number	e242485
Journal	BMJ case reports
Volume	14
Issue number	6
DOIs	https://doi.org/10.1136/bcr-2021-242485
State	Published - Jun 10 2021

Keywords

haematology (incl blood transfusion)
infections
malignant disease and immunosuppression
pneumonia (infectious disease)

ASJC Scopus subject areas

Medicine(all)

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10.1136/bcr-2021-242485

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abstract = "Two patients receiving oral etoposide therapy developed Pneumocystis jirovecii pneumonia during chemotherapy with significant lymphopenia without corticosteroid use. In this commentary we discuss cellular mechanisms by which etoposide induced CD4+ T lymphocyte dysfunction and reduced survival may lead to predisposition to P. jirovecii infection.",

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AB - Two patients receiving oral etoposide therapy developed Pneumocystis jirovecii pneumonia during chemotherapy with significant lymphopenia without corticosteroid use. In this commentary we discuss cellular mechanisms by which etoposide induced CD4+ T lymphocyte dysfunction and reduced survival may lead to predisposition to P. jirovecii infection.

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Pneumocystis jirovecii pneumonia as a complication of etoposide therapy

Abstract

Keywords

ASJC Scopus subject areas

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