Pluripotency of embryonic stem cells

Satoshi Yamanaka, Jinliang Li, Gabriela Kania, Steve Elliott, Robert P. Wersto, Jennifer Van Eyk, Anna M. Wobus, Kenneth R. Boheler

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Embryonic stem (ES) cells derived from pre-implantation embryos have the potential to differentiate into any cell type derived from the three germ layers of ectoderm (epidermal tissues and nerves), mesoderm (muscle, bone, blood), and endoderm (liver, pancreas, gastrointestinal tract, lungs), including fetal and adult cells. Alone, these cells do not develop into a viable fetus or adult animal because they do not retain the potential to contribute to extraembryonic tissue, and in vitro, they lack spatial and temporal signaling cues essential to normal in vivo development. The basis of pluripotentiality resides in conserved regulatory networks composed of numerous transcription factors and multiple signaling cascades. Together, these regulatory networks maintain ES cells in a pluripotent and undifferentiated form; however, alterations in the stoichiometry of these signals promote differentiation. By taking advantage of this differentiation capacity in vitro, ES cells have clearly been shown to possess the potential to generate multipotent stem and progenitor cells capable of differentiating into a limited number of cell fates. These latter types of cells may prove to be therapeutically viable, but perhaps more importantly, the studies of these cells have led to a greater understanding of mammalian development.

Original languageEnglish
Pages (from-to)5-22
Number of pages18
JournalCell and Tissue Research
Volume331
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Embryonic Stem Cells
Stem cells
Tissue
Stoichiometry
Liver
Muscle
Multipotent Stem Cells
Bone
Animals
Blood
Transcription Factors
Nerve Tissue
Germ Layers
Endoderm
Ectoderm
Mesoderm
Cues
Gastrointestinal Tract
Pancreas
Fetus

Keywords

  • Development
  • Differentiation
  • Embryonic stem cells
  • Pluripotency

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Yamanaka, S., Li, J., Kania, G., Elliott, S., Wersto, R. P., Van Eyk, J., ... Boheler, K. R. (2008). Pluripotency of embryonic stem cells. Cell and Tissue Research, 331(1), 5-22. https://doi.org/10.1007/s00441-007-0520-5

Pluripotency of embryonic stem cells. / Yamanaka, Satoshi; Li, Jinliang; Kania, Gabriela; Elliott, Steve; Wersto, Robert P.; Van Eyk, Jennifer; Wobus, Anna M.; Boheler, Kenneth R.

In: Cell and Tissue Research, Vol. 331, No. 1, 01.01.2008, p. 5-22.

Research output: Contribution to journalArticle

Yamanaka, S, Li, J, Kania, G, Elliott, S, Wersto, RP, Van Eyk, J, Wobus, AM & Boheler, KR 2008, 'Pluripotency of embryonic stem cells', Cell and Tissue Research, vol. 331, no. 1, pp. 5-22. https://doi.org/10.1007/s00441-007-0520-5
Yamanaka S, Li J, Kania G, Elliott S, Wersto RP, Van Eyk J et al. Pluripotency of embryonic stem cells. Cell and Tissue Research. 2008 Jan 1;331(1):5-22. https://doi.org/10.1007/s00441-007-0520-5
Yamanaka, Satoshi ; Li, Jinliang ; Kania, Gabriela ; Elliott, Steve ; Wersto, Robert P. ; Van Eyk, Jennifer ; Wobus, Anna M. ; Boheler, Kenneth R. / Pluripotency of embryonic stem cells. In: Cell and Tissue Research. 2008 ; Vol. 331, No. 1. pp. 5-22.
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