Pluripotency and epigenetic factors in mouse embryonic stem cell fate regulation

Lluis Morey, Alexandra Santanach, Luciano di Crocea

Research output: Contribution to journalShort survey

47 Scopus citations

Abstract

Embryonic stem cells (ESCs) are characterized by their ability to self-renew and to differentiate into all cell types of a given organism. Understanding the molecular mechanisms that govern the ESC state is of great interest not only for basic research-for instance, ESCs represent a perfect system to study cellular differentiation in vitro-but also for their potential implications in human health, as these mechanisms are likewise involved in cancer progression and could be exploited in regenerative medicine. In this minireview, we focus on the latest insights into the molecular mechanisms mediated by the pluripotency factors as well as their roles during differentiation. We also discuss recent advances in understanding the function of the epigenetic regulators, Polycomb and MLL complexes, in ESC biology.

Original languageEnglish (US)
Pages (from-to)2716-2728
Number of pages13
JournalMolecular and cellular biology
Volume35
Issue number16
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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