Platinum-based compounds and risk for cardiovascular toxicity in the elderly: Role of the antioxidants in chemoprevention

Patrizia Ferroni, David Della Morte, Raffaele Palmirotta, Mark McClendon, Gianluca Testa, Pasquale Abete, Franco Rengo, Tatjana Rundek, Fiorella Guadagni, Mario Roselli

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Cancer in elderly patients is an increasingly common problem. Older patients have more co-morbidity, therefore the toxic effects of chemotherapy treatment are less tolerable compared to younger patients. Platinum-based compounds (PBCs) are commonly used cytotoxic agents in the treatment of several solid tumors; however, their application is still limited in elderly patients, due to the risks in cardiovascular toxicity. The increased risk for myocardial ischemia, stroke, and vascular thrombosis linked with PBCs treatment is mainly due to reactive oxygen species (ROS) production and the subsequent induction of oxidative stress and switch to a prothrombotic condition. Recently, studies have shown a different genetic susceptibility in cardiovascular toxicity induced by therapy with PBCs. Antioxidants, such as vitamin E, selenium, lycopene, melatonin, and resveratrol, have been implicated in cancer treatment by their property to suppress the oxidant injury. Resveratrol, especially, has been shown to increase the antineoplastic activity of cisplatin. In addition, resveratrol's ability to activate the sirtuin1 (SIRT1) pathway has been heavily implicated in the mechanisms controlling longevity and quality of life in the aged population. This article reviews the current state of treatment with PBCs and their associated risk for cardiovascular disease. It discusses the most powerful antioxidant supplementation options as a possible strategy to reduce the cardiovascular toxicity effects of chemotherapy in the elderly.

Original languageEnglish
Pages (from-to)293-308
Number of pages16
JournalRejuvenation Research
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2011

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Platinum Compounds
Chemoprevention
Antioxidants
Therapeutics
Drug Therapy
Neoplasms
Poisons
Cytotoxins
Melatonin
Genetic Predisposition to Disease
Selenium
Vitamin E
Oxidants
Antineoplastic Agents
Cisplatin
Myocardial Ischemia
Blood Vessels
Reactive Oxygen Species
Oxidative Stress
Thrombosis

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Platinum-based compounds and risk for cardiovascular toxicity in the elderly : Role of the antioxidants in chemoprevention. / Ferroni, Patrizia; Della Morte, David; Palmirotta, Raffaele; McClendon, Mark; Testa, Gianluca; Abete, Pasquale; Rengo, Franco; Rundek, Tatjana; Guadagni, Fiorella; Roselli, Mario.

In: Rejuvenation Research, Vol. 14, No. 3, 01.06.2011, p. 293-308.

Research output: Contribution to journalArticle

Ferroni, Patrizia ; Della Morte, David ; Palmirotta, Raffaele ; McClendon, Mark ; Testa, Gianluca ; Abete, Pasquale ; Rengo, Franco ; Rundek, Tatjana ; Guadagni, Fiorella ; Roselli, Mario. / Platinum-based compounds and risk for cardiovascular toxicity in the elderly : Role of the antioxidants in chemoprevention. In: Rejuvenation Research. 2011 ; Vol. 14, No. 3. pp. 293-308.
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