Platelet satellitism and dual surface immunoglobulin light-chain expression in circulating splenic marginal zone lymphoma cells

Naomi Montague, Patricia Blackwelder, Husain Alsayegh, Roberto Ochoa, Ximena Vial, Gerald E. Byrne

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid-anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalAnnals of Diagnostic Pathology
Volume17
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • Dual light chain expression
  • Flow cytometry
  • Lymphoma
  • Satellitism
  • Scanning electron microscopy (SEM)
  • Transmission electron microscopy (TEM)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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