Platelet-rich plasma: Growth factor enhancement for bone grafts

Robert Marx, Eric R. Carlson, Ralph M. Eichstaedt, Steven R. Schimmele, James E. Strauss, Karen R. Georgeff

Research output: Contribution to journalArticle

1734 Citations (Scopus)

Abstract

Platelet-rich plasma is an autologous source of platelet-derived growth factor and transforming growth factor beta that is obtained by sequestering and concentrating platelets by gradient density centrifugation. This technique produced a concentration of human platelets of 338% and identified platelet-derived growth factor and transforming growth factor beta within them. Monoclonal antibody assessment of cancellous cellular marrow grafts demonstrated cells that were capable of responding to the growth factors by bearing cell membrane receptors. The additional amounts of these growth factors obtained by adding plateletrich plasma to grafts evidenced a radiographic maturation rate 1.62 to 2.16 times that of grafts without platelet-rich plasma. As assessed by histomorphometry, there was also a greater bone density in grafts in which platelet-rich plasma was added (74.0% ± 11%) than in grafts in which platelet-rich plasma was not added (55.1 % ± 8%; p = 0.005).

Original languageEnglish
Pages (from-to)638-646
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume85
Issue number6
StatePublished - Dec 1 1998

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Immunologic Graft Enhancement
Platelet-Rich Plasma
Intercellular Signaling Peptides and Proteins
Transplants
Bone and Bones
Platelet-Derived Growth Factor
Transforming Growth Factor beta
Blood Platelets
Density Gradient Centrifugation
Bone Density
Bone Marrow
Monoclonal Antibodies
Cell Membrane

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Marx, R., Carlson, E. R., Eichstaedt, R. M., Schimmele, S. R., Strauss, J. E., & Georgeff, K. R. (1998). Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 85(6), 638-646.

Platelet-rich plasma : Growth factor enhancement for bone grafts. / Marx, Robert; Carlson, Eric R.; Eichstaedt, Ralph M.; Schimmele, Steven R.; Strauss, James E.; Georgeff, Karen R.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 85, No. 6, 01.12.1998, p. 638-646.

Research output: Contribution to journalArticle

Marx, R, Carlson, ER, Eichstaedt, RM, Schimmele, SR, Strauss, JE & Georgeff, KR 1998, 'Platelet-rich plasma: Growth factor enhancement for bone grafts', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 85, no. 6, pp. 638-646.
Marx R, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 1998 Dec 1;85(6):638-646.
Marx, Robert ; Carlson, Eric R. ; Eichstaedt, Ralph M. ; Schimmele, Steven R. ; Strauss, James E. ; Georgeff, Karen R. / Platelet-rich plasma : Growth factor enhancement for bone grafts. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 1998 ; Vol. 85, No. 6. pp. 638-646.
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