Platelet-rich plasma: Growth factor enhancement for bone grafts

Robert E. Marx, Eric R. Carlson, Ralph M. Eichstaedt, Steven R. Schimmele, James E. Strauss, Karen R. Georgeff

Research output: Contribution to journalArticle

1813 Scopus citations

Abstract

Platelet-rich plasma is an autologous source of platelet-derived growth factor and transforming growth factor beta that is obtained by sequestering and concentrating platelets by gradient density centrifugation. This technique produced a concentration of human platelets of 338% and identified platelet-derived growth factor and transforming growth factor beta within them. Monoclonal antibody assessment of cancellous cellular marrow grafts demonstrated cells that were capable of responding to the growth factors by bearing cell membrane receptors. The additional amounts of these growth factors obtained by adding plateletrich plasma to grafts evidenced a radiographic maturation rate 1.62 to 2.16 times that of grafts without platelet-rich plasma. As assessed by histomorphometry, there was also a greater bone density in grafts in which platelet-rich plasma was added (74.0% ± 11%) than in grafts in which platelet-rich plasma was not added (55.1 % ± 8%; p = 0.005).

Original languageEnglish (US)
Pages (from-to)638-646
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume85
Issue number6
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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