Platelet-rich plasma for bone graft enhancement in sinus floor augmentation with simultaneous implant placement: Patient series study

Ziv Mazor, Michael Peleg, Arun K. Garg, Jacob Luboshitz

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The use of autologous platelet-rich plasma (PRP) as a source for growth factors in bone grafting is a relatively new and promising technique. Early controlled studies indicate that combining PRP with autologous bone grafts significantly enhances the rate of bone formation and maturation. The study consisted of 105 patients who required sinus augmentation with crestal bone height of less than 5 mm in the posterior maxilla. All patients received a composite bone graft that consisted of 30% to 40% autogenous bone harvested from the lateral wall of the maxilla zygomatic-maxillary buttress and the tuberosity and 60% to 70% xenograft. A total of 50 mL of blood was obtained from each patient before the surgical treatment for preparation of 10 mL of PRP. The graft-PRP mixture was activated by human thrombin. All sinus augmentations were carried out simultaneously with dental implants. At 6 months postoperatively, implants were exposed showing no clinical evidence of crestal bone loss around the implants both clinically and radio graphically. All implants were clinically osseointegrated and loaded with fixed porcelain fused to metal prosthesis. The use of PRP in augmenting the severely atrophic posterior maxilla has obvious clinical benefits in terms of reducing the healing period of bone maturation, better graft handling, and accelerated soft tissue healing.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalImplant Dentistry
Volume13
Issue number1
DOIs
StatePublished - Mar 1 2004

Fingerprint

Immunologic Graft Enhancement
Sinus Floor Augmentation
Platelet-Rich Plasma
Bone and Bones
Maxilla
Transplants
Dental Porcelain
Dental Implants
Bone Transplantation
Radio
Heterografts
Osteogenesis
Thrombin
Prostheses and Implants
Intercellular Signaling Peptides and Proteins
Metals

Keywords

  • Bone augmentation
  • Dental implants
  • Growth factors
  • Platelet-rich plasma

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Platelet-rich plasma for bone graft enhancement in sinus floor augmentation with simultaneous implant placement : Patient series study. / Mazor, Ziv; Peleg, Michael; Garg, Arun K.; Luboshitz, Jacob.

In: Implant Dentistry, Vol. 13, No. 1, 01.03.2004, p. 65-72.

Research output: Contribution to journalArticle

@article{8de6aa3b3a664400bb662d4e3162e52a,
title = "Platelet-rich plasma for bone graft enhancement in sinus floor augmentation with simultaneous implant placement: Patient series study",
abstract = "The use of autologous platelet-rich plasma (PRP) as a source for growth factors in bone grafting is a relatively new and promising technique. Early controlled studies indicate that combining PRP with autologous bone grafts significantly enhances the rate of bone formation and maturation. The study consisted of 105 patients who required sinus augmentation with crestal bone height of less than 5 mm in the posterior maxilla. All patients received a composite bone graft that consisted of 30{\%} to 40{\%} autogenous bone harvested from the lateral wall of the maxilla zygomatic-maxillary buttress and the tuberosity and 60{\%} to 70{\%} xenograft. A total of 50 mL of blood was obtained from each patient before the surgical treatment for preparation of 10 mL of PRP. The graft-PRP mixture was activated by human thrombin. All sinus augmentations were carried out simultaneously with dental implants. At 6 months postoperatively, implants were exposed showing no clinical evidence of crestal bone loss around the implants both clinically and radio graphically. All implants were clinically osseointegrated and loaded with fixed porcelain fused to metal prosthesis. The use of PRP in augmenting the severely atrophic posterior maxilla has obvious clinical benefits in terms of reducing the healing period of bone maturation, better graft handling, and accelerated soft tissue healing.",
keywords = "Bone augmentation, Dental implants, Growth factors, Platelet-rich plasma",
author = "Ziv Mazor and Michael Peleg and Garg, {Arun K.} and Jacob Luboshitz",
year = "2004",
month = "3",
day = "1",
doi = "10.1097/01.ID.0000116454.97671.40",
language = "English",
volume = "13",
pages = "65--72",
journal = "Implant Dentistry",
issn = "1056-6163",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Platelet-rich plasma for bone graft enhancement in sinus floor augmentation with simultaneous implant placement

T2 - Patient series study

AU - Mazor, Ziv

AU - Peleg, Michael

AU - Garg, Arun K.

AU - Luboshitz, Jacob

PY - 2004/3/1

Y1 - 2004/3/1

N2 - The use of autologous platelet-rich plasma (PRP) as a source for growth factors in bone grafting is a relatively new and promising technique. Early controlled studies indicate that combining PRP with autologous bone grafts significantly enhances the rate of bone formation and maturation. The study consisted of 105 patients who required sinus augmentation with crestal bone height of less than 5 mm in the posterior maxilla. All patients received a composite bone graft that consisted of 30% to 40% autogenous bone harvested from the lateral wall of the maxilla zygomatic-maxillary buttress and the tuberosity and 60% to 70% xenograft. A total of 50 mL of blood was obtained from each patient before the surgical treatment for preparation of 10 mL of PRP. The graft-PRP mixture was activated by human thrombin. All sinus augmentations were carried out simultaneously with dental implants. At 6 months postoperatively, implants were exposed showing no clinical evidence of crestal bone loss around the implants both clinically and radio graphically. All implants were clinically osseointegrated and loaded with fixed porcelain fused to metal prosthesis. The use of PRP in augmenting the severely atrophic posterior maxilla has obvious clinical benefits in terms of reducing the healing period of bone maturation, better graft handling, and accelerated soft tissue healing.

AB - The use of autologous platelet-rich plasma (PRP) as a source for growth factors in bone grafting is a relatively new and promising technique. Early controlled studies indicate that combining PRP with autologous bone grafts significantly enhances the rate of bone formation and maturation. The study consisted of 105 patients who required sinus augmentation with crestal bone height of less than 5 mm in the posterior maxilla. All patients received a composite bone graft that consisted of 30% to 40% autogenous bone harvested from the lateral wall of the maxilla zygomatic-maxillary buttress and the tuberosity and 60% to 70% xenograft. A total of 50 mL of blood was obtained from each patient before the surgical treatment for preparation of 10 mL of PRP. The graft-PRP mixture was activated by human thrombin. All sinus augmentations were carried out simultaneously with dental implants. At 6 months postoperatively, implants were exposed showing no clinical evidence of crestal bone loss around the implants both clinically and radio graphically. All implants were clinically osseointegrated and loaded with fixed porcelain fused to metal prosthesis. The use of PRP in augmenting the severely atrophic posterior maxilla has obvious clinical benefits in terms of reducing the healing period of bone maturation, better graft handling, and accelerated soft tissue healing.

KW - Bone augmentation

KW - Dental implants

KW - Growth factors

KW - Platelet-rich plasma

UR - http://www.scopus.com/inward/record.url?scp=2342655816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342655816&partnerID=8YFLogxK

U2 - 10.1097/01.ID.0000116454.97671.40

DO - 10.1097/01.ID.0000116454.97671.40

M3 - Article

C2 - 15017307

AN - SCOPUS:2342655816

VL - 13

SP - 65

EP - 72

JO - Implant Dentistry

JF - Implant Dentistry

SN - 1056-6163

IS - 1

ER -