Platelet-derived growth factor receptor-β in Gorham's disease

Jeroen Hagendoorn, Timothy P. Padera, Torunn I. Yock, G. Petur Nielsen, Emmanuelle di Tomaso, Dan G. Duda, Thomas F. Delaney, Henning A. Gaissert, Jennifer Pearce, Andrew Rosenberg, Rakesh K. Jain, David H. Ebb

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower-left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion. Investigations: Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays. Diagnosis: Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-β and elevated circulating platelet-derived growth factor-BB. Management: Spine stabilization, thalidomide, celecoxib, interferon-α2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalNature Clinical Practice Oncology
Volume3
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Essential Osteolysis
Platelet-Derived Growth Factor Receptors
pamidronate
zoledronic acid
Celecoxib
Ribs
Spine
Thorax
Pleurodesis
Thoracic Vertebrae
Talc
A 17
Thalidomide
Thoracic Wall
Pleural Effusion
Thoracotomy
Back Pain
Interferons
Physical Examination
Flow Cytometry

ASJC Scopus subject areas

  • Oncology

Cite this

Hagendoorn, J., Padera, T. P., Yock, T. I., Nielsen, G. P., di Tomaso, E., Duda, D. G., ... Ebb, D. H. (2006). Platelet-derived growth factor receptor-β in Gorham's disease. Nature Clinical Practice Oncology, 3(12), 693-697. https://doi.org/10.1038/ncponc0660

Platelet-derived growth factor receptor-β in Gorham's disease. / Hagendoorn, Jeroen; Padera, Timothy P.; Yock, Torunn I.; Nielsen, G. Petur; di Tomaso, Emmanuelle; Duda, Dan G.; Delaney, Thomas F.; Gaissert, Henning A.; Pearce, Jennifer; Rosenberg, Andrew; Jain, Rakesh K.; Ebb, David H.

In: Nature Clinical Practice Oncology, Vol. 3, No. 12, 01.12.2006, p. 693-697.

Research output: Contribution to journalArticle

Hagendoorn, J, Padera, TP, Yock, TI, Nielsen, GP, di Tomaso, E, Duda, DG, Delaney, TF, Gaissert, HA, Pearce, J, Rosenberg, A, Jain, RK & Ebb, DH 2006, 'Platelet-derived growth factor receptor-β in Gorham's disease', Nature Clinical Practice Oncology, vol. 3, no. 12, pp. 693-697. https://doi.org/10.1038/ncponc0660
Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG et al. Platelet-derived growth factor receptor-β in Gorham's disease. Nature Clinical Practice Oncology. 2006 Dec 1;3(12):693-697. https://doi.org/10.1038/ncponc0660
Hagendoorn, Jeroen ; Padera, Timothy P. ; Yock, Torunn I. ; Nielsen, G. Petur ; di Tomaso, Emmanuelle ; Duda, Dan G. ; Delaney, Thomas F. ; Gaissert, Henning A. ; Pearce, Jennifer ; Rosenberg, Andrew ; Jain, Rakesh K. ; Ebb, David H. / Platelet-derived growth factor receptor-β in Gorham's disease. In: Nature Clinical Practice Oncology. 2006 ; Vol. 3, No. 12. pp. 693-697.
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