Platelet-derived growth factor receptor-β in Gorham's disease

Jeroen Hagendoorn, Timothy P. Padera, Torunn I. Yock, G. Petur Nielsen, Emmanuelle di Tomaso, Dan G. Duda, Thomas F. Delaney, Henning A. Gaissert, Jennifer Pearce, Andrew E. Rosenberg, Rakesh K. Jain, David H. Ebb

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Background: A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower-left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion. Investigations: Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays. Diagnosis: Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-β and elevated circulating platelet-derived growth factor-BB. Management: Spine stabilization, thalidomide, celecoxib, interferon-α2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.

Original languageEnglish (US)
Pages (from-to)693-697
Number of pages5
JournalNature Clinical Practice Oncology
Volume3
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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    Hagendoorn, J., Padera, T. P., Yock, T. I., Nielsen, G. P., di Tomaso, E., Duda, D. G., Delaney, T. F., Gaissert, H. A., Pearce, J., Rosenberg, A. E., Jain, R. K., & Ebb, D. H. (2006). Platelet-derived growth factor receptor-β in Gorham's disease. Nature Clinical Practice Oncology, 3(12), 693-697. https://doi.org/10.1038/ncponc0660