Plasticity and cytokinetic dynamics of the hair follicle mesenchyme during the hair growth cycle: Implications for growth control and hair follicle transformations

Desmond J. Tobin, Andrei Gunin, Markus Magerl, Ralf Paus

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Hair fiber production is the macroscopic end-point of a highly complex set of interactions between the hair follicle's epithelial and mesenchymal components. The nature of this relationship is largely set during hair follicle morphogenesis, but is dramatically revisited in the adult during the unique tissue remodeling events required for hair follicle cycling. Whereas significant attention has focused on the fate of the hair follicle epithelium during these events, associated changes in hair follicle fibroblast subpopulations remain unclear. Here, we present a speculative review that represents a critical and innovative synthesis of the current literature and summarizes a recently submitted original study by the authors, on the nature of hair cycle-dependent fibroblast dynamics and on how perturbations thereof may lead to several clinical manifestations of altered human hair growth.

Original languageEnglish (US)
Pages (from-to)80-86
Number of pages7
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Hair Follicle
Mesoderm
Hair
Growth
Fibroblasts
Morphogenesis
Epithelium

Keywords

  • Apoptosis
  • Connective tissue sheath
  • Electron microscopy
  • Follicular or dermal papilla
  • Proliferation

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

@article{55a73f61540448e5af1ac52f2588d02a,
title = "Plasticity and cytokinetic dynamics of the hair follicle mesenchyme during the hair growth cycle: Implications for growth control and hair follicle transformations",
abstract = "Hair fiber production is the macroscopic end-point of a highly complex set of interactions between the hair follicle's epithelial and mesenchymal components. The nature of this relationship is largely set during hair follicle morphogenesis, but is dramatically revisited in the adult during the unique tissue remodeling events required for hair follicle cycling. Whereas significant attention has focused on the fate of the hair follicle epithelium during these events, associated changes in hair follicle fibroblast subpopulations remain unclear. Here, we present a speculative review that represents a critical and innovative synthesis of the current literature and summarizes a recently submitted original study by the authors, on the nature of hair cycle-dependent fibroblast dynamics and on how perturbations thereof may lead to several clinical manifestations of altered human hair growth.",
keywords = "Apoptosis, Connective tissue sheath, Electron microscopy, Follicular or dermal papilla, Proliferation",
author = "Tobin, {Desmond J.} and Andrei Gunin and Markus Magerl and Ralf Paus",
year = "2003",
month = "1",
day = "1",
doi = "10.1046/j.1523-1747.2003.12177.x",
language = "English (US)",
volume = "8",
pages = "80--86",
journal = "Journal of Investigative Dermatology Symposium Proceedings",
issn = "1087-0024",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Plasticity and cytokinetic dynamics of the hair follicle mesenchyme during the hair growth cycle

T2 - Implications for growth control and hair follicle transformations

AU - Tobin, Desmond J.

AU - Gunin, Andrei

AU - Magerl, Markus

AU - Paus, Ralf

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Hair fiber production is the macroscopic end-point of a highly complex set of interactions between the hair follicle's epithelial and mesenchymal components. The nature of this relationship is largely set during hair follicle morphogenesis, but is dramatically revisited in the adult during the unique tissue remodeling events required for hair follicle cycling. Whereas significant attention has focused on the fate of the hair follicle epithelium during these events, associated changes in hair follicle fibroblast subpopulations remain unclear. Here, we present a speculative review that represents a critical and innovative synthesis of the current literature and summarizes a recently submitted original study by the authors, on the nature of hair cycle-dependent fibroblast dynamics and on how perturbations thereof may lead to several clinical manifestations of altered human hair growth.

AB - Hair fiber production is the macroscopic end-point of a highly complex set of interactions between the hair follicle's epithelial and mesenchymal components. The nature of this relationship is largely set during hair follicle morphogenesis, but is dramatically revisited in the adult during the unique tissue remodeling events required for hair follicle cycling. Whereas significant attention has focused on the fate of the hair follicle epithelium during these events, associated changes in hair follicle fibroblast subpopulations remain unclear. Here, we present a speculative review that represents a critical and innovative synthesis of the current literature and summarizes a recently submitted original study by the authors, on the nature of hair cycle-dependent fibroblast dynamics and on how perturbations thereof may lead to several clinical manifestations of altered human hair growth.

KW - Apoptosis

KW - Connective tissue sheath

KW - Electron microscopy

KW - Follicular or dermal papilla

KW - Proliferation

UR - http://www.scopus.com/inward/record.url?scp=0041868104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041868104&partnerID=8YFLogxK

U2 - 10.1046/j.1523-1747.2003.12177.x

DO - 10.1046/j.1523-1747.2003.12177.x

M3 - Article

C2 - 12895000

AN - SCOPUS:0041868104

VL - 8

SP - 80

EP - 86

JO - Journal of Investigative Dermatology Symposium Proceedings

JF - Journal of Investigative Dermatology Symposium Proceedings

SN - 1087-0024

IS - 1

ER -