Abstract
The drugs 2,4-diamino-6-(2-naphthyl-sulfonyl)-quinazoline (WR 158,122)and its tetrahydro analog (WR 180,872) were found to act synergistically in reducing the parasitemia of Plasmodium berghei infected mice. Evidence was found that both the drugs which are potent folic acid antagonists were acting at different sites in the folic acid metabolic pathway, neither of which was at the action site of p-aminobenzoic acid (PABA)inhibitors. Advantages of drug combinations in malaria chemotherapy are discussed.
Original language | English (US) |
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Pages (from-to) | 95-102 |
Number of pages | 8 |
Journal | Experimental Parasitology |
Volume | 40 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1976 |
Keywords
- Antifols
- Chemotherapy, malaria
- Combined drug therapy
- Dihydrofolate reductase inhibitors
- Drug antagonism
- Drug combinations
- Drug synergism
- Enzymes
- Folic acid
- Inhibitors, metabolic
- Malaria
- Metabolic inhibitors
- Mice
- Plasmodium berghei
- p-Aminobenzoic acid
ASJC Scopus subject areas
- Parasitology
- Immunology
- Infectious Diseases