Plasminogen activator and nuclear androgen receptor in rat prostate tumors after treatment with D-Trp-6-LH-RH

M. T. Hierowski, O. Wettler, A. V. Schally

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Plasminogen activator and nonspecific proteolytic activity in transplantable squamous cell rat prostate tumor 11095 were measured by a fluorometric method. Prostate tumors which regressed after treatment with D-Trp-6-LH-RH had 10-fold lower concentrations of plasminogen activator(s) per mg of protein, and considerably higher levels of nuclear androgen receptor. On the other hand, there were no significant changes in nonspecific proteolytic activity in tumor tissue between untreated and D-Trp-6-LH-RH treated rats. The prostate tumor had at least three different plasminogen activator-like bands, as determined by polyacrylamide gel electrophoresis with plasminogen as substrate. The decreased activity of plasminogen activator(s) and considerably higher levels of nuclear androgen receptors correlate with the regression of prostate tumors induced by the treatment of rats with D-Trp-6-LH-RH.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalBiomedicine and Pharmacotherapy
Volume38
Issue number6
StatePublished - Dec 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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