Plasma somatomedin‐C levels in systemic sclerosis

M. J. ROTHE; R. D. ALTMAN; V. FALANGA

doi:10.1111/j.1365-2133.1988.tb03476.x

Plasma somatomedin‐C levels in systemic sclerosis

M. J. ROTHE, R. D. ALTMAN, V. FALANGA

Medicine

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Abstract

We have measured the plasma levels of somatomedin‐C (SM‐C) or insulin‐like growth factor I (IGF‐I) in 13 patients with progressive systemic sclerosis (PSS) and age and sex matched healthy controls. We found the plasma SM‐C levels to be within normal limits in all the patients. Thus, if somatomedin‐C plays a role in the pathogenesis of PSS, it is more likely to be at the fibroblast receptor level or in the synthetic response of fibroblasts to SM‐C.

Original language	English (US)
Pages (from-to)	639-642
Number of pages	4
Journal	British Journal of Dermatology
Volume	119
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2133.1988.tb03476.x
State	Published - Nov 1988

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ASJC Scopus subject areas

Dermatology

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ROTHE, M. J., ALTMAN, R. D., & FALANGA, V. (1988). Plasma somatomedin‐C levels in systemic sclerosis. British Journal of Dermatology, 119(5), 639-642. https://doi.org/10.1111/j.1365-2133.1988.tb03476.x

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10.1111/j.1365-2133.1988.tb03476.x