Abstract
Increased plasma sialidase activity was demonstrated in 25 patients with acute myocardial infarction. The mean plasma sialic lcid level after incubation with substrate neuramin lactose was 0.060 ± 0.003 (SEM) μmol/sample compared with 0.017 ± 0.003 μmol/sample in 24 patients without infarction (p < 0.001). The erythrocyte endothelial cell adhesion index was highest when both cell types were sialidase treated (0.35 vs control 0.00 [p < 0.05]). When sialidase (50 U/ml) was added to whole blood in plastic tubes, the mean clotting time was 7.17 ± 1.0 (SD) minutes (n = 8) compared with a mean control of 15.45 ± 3.9 minutes (p < 0.01). Sialidase had no effect on prothrombin or partial thromboplastin times. The above studies suggest that increased plasma sialidase activity in patients with acute myocardial infarction may be associated with clumps of desialylated erythrocytes that may alter flow in the microcirculation.
| Original language | English |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | American Heart Journal |
| Volume | 114 |
| Issue number | 1 PART 1 |
| DOIs | |
| State | Published - Jan 1 1987 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Plasma sialidase activity in acute myocardial infarction. / Hanson, Victor A.; Shettigar, Udipi R.; Loungani, Ramesh R.; Nadijcka, Mary D.
In: American Heart Journal, Vol. 114, No. 1 PART 1, 01.01.1987, p. 59-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma sialidase activity in acute myocardial infarction
AU - Hanson, Victor A.
AU - Shettigar, Udipi R.
AU - Loungani, Ramesh R.
AU - Nadijcka, Mary D.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Increased plasma sialidase activity was demonstrated in 25 patients with acute myocardial infarction. The mean plasma sialic lcid level after incubation with substrate neuramin lactose was 0.060 ± 0.003 (SEM) μmol/sample compared with 0.017 ± 0.003 μmol/sample in 24 patients without infarction (p < 0.001). The erythrocyte endothelial cell adhesion index was highest when both cell types were sialidase treated (0.35 vs control 0.00 [p < 0.05]). When sialidase (50 U/ml) was added to whole blood in plastic tubes, the mean clotting time was 7.17 ± 1.0 (SD) minutes (n = 8) compared with a mean control of 15.45 ± 3.9 minutes (p < 0.01). Sialidase had no effect on prothrombin or partial thromboplastin times. The above studies suggest that increased plasma sialidase activity in patients with acute myocardial infarction may be associated with clumps of desialylated erythrocytes that may alter flow in the microcirculation.
AB - Increased plasma sialidase activity was demonstrated in 25 patients with acute myocardial infarction. The mean plasma sialic lcid level after incubation with substrate neuramin lactose was 0.060 ± 0.003 (SEM) μmol/sample compared with 0.017 ± 0.003 μmol/sample in 24 patients without infarction (p < 0.001). The erythrocyte endothelial cell adhesion index was highest when both cell types were sialidase treated (0.35 vs control 0.00 [p < 0.05]). When sialidase (50 U/ml) was added to whole blood in plastic tubes, the mean clotting time was 7.17 ± 1.0 (SD) minutes (n = 8) compared with a mean control of 15.45 ± 3.9 minutes (p < 0.01). Sialidase had no effect on prothrombin or partial thromboplastin times. The above studies suggest that increased plasma sialidase activity in patients with acute myocardial infarction may be associated with clumps of desialylated erythrocytes that may alter flow in the microcirculation.
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U2 - 10.1016/0002-8703(87)90307-3
DO - 10.1016/0002-8703(87)90307-3
M3 - Article
VL - 114
SP - 59
EP - 63
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1 PART 1
ER -