Plasma sialidase activity in acute myocardial infarction

Victor A. Hanson, Udipi R. Shettigar, Ramesh R. Loungani, Mary D. Nadijcka

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Increased plasma sialidase activity was demonstrated in 25 patients with acute myocardial infarction. The mean plasma sialic lcid level after incubation with substrate neuramin lactose was 0.060 ± 0.003 (SEM) μmol/sample compared with 0.017 ± 0.003 μmol/sample in 24 patients without infarction (p < 0.001). The erythrocyte endothelial cell adhesion index was highest when both cell types were sialidase treated (0.35 vs control 0.00 [p < 0.05]). When sialidase (50 U/ml) was added to whole blood in plastic tubes, the mean clotting time was 7.17 ± 1.0 (SD) minutes (n = 8) compared with a mean control of 15.45 ± 3.9 minutes (p < 0.01). Sialidase had no effect on prothrombin or partial thromboplastin times. The above studies suggest that increased plasma sialidase activity in patients with acute myocardial infarction may be associated with clumps of desialylated erythrocytes that may alter flow in the microcirculation.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalAmerican Heart Journal
Volume114
Issue number1 PART 1
DOIs
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Hanson, V. A., Shettigar, U. R., Loungani, R. R., & Nadijcka, M. D. (1987). Plasma sialidase activity in acute myocardial infarction. American Heart Journal, 114(1 PART 1), 59-63. https://doi.org/10.1016/0002-8703(87)90307-3