Plasma-serum differences in the assessment of tricyclic antidepressant blood levels

Emil F. Coccaro; Federico Adan; David Allen; Thomas B. Cooper

doi:10.1097/00004850-198707000-00004

Plasma-serum differences in the assessment of tricyclic antidepressant blood levels

Emil F. Coccaro, Federico Adan, David Allen, Thomas B. Cooper

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Concomitant plasma and serum tricyclic determinations were performed on 20 patients chronically administered imipramine (N = 10), amitriptyline (N = 10), desipramine (N = 10), and nortriptyline (N = 10). Plasma levels for these tricyclic antidepressants were significantly greater than the corresponding serum levels. Plasma-serum differences for the secondary amines (DMI/NT) were more than twice those for the tertiary amines (IMI/AMI). The authors thus suggest that clinicians and investigators specify the specific source of blood sample when assessing blood levels of the secondary tricyclic antidepressants.

Original language	English (US)
Pages (from-to)	217-224
Number of pages	8
Journal	International Clinical Psychopharmacology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1097/00004850-198707000-00004
State	Published - Jul 1987

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

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abstract = "Concomitant plasma and serum tricyclic determinations were performed on 20 patients chronically administered imipramine (N = 10), amitriptyline (N = 10), desipramine (N = 10), and nortriptyline (N = 10). Plasma levels for these tricyclic antidepressants were significantly greater than the corresponding serum levels. Plasma-serum differences for the secondary amines (DMI/NT) were more than twice those for the tertiary amines (IMI/AMI). The authors thus suggest that clinicians and investigators specify the specific source of blood sample when assessing blood levels of the secondary tricyclic antidepressants.",

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AB - Concomitant plasma and serum tricyclic determinations were performed on 20 patients chronically administered imipramine (N = 10), amitriptyline (N = 10), desipramine (N = 10), and nortriptyline (N = 10). Plasma levels for these tricyclic antidepressants were significantly greater than the corresponding serum levels. Plasma-serum differences for the secondary amines (DMI/NT) were more than twice those for the tertiary amines (IMI/AMI). The authors thus suggest that clinicians and investigators specify the specific source of blood sample when assessing blood levels of the secondary tricyclic antidepressants.

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Plasma-serum differences in the assessment of tricyclic antidepressant blood levels

Abstract

ASJC Scopus subject areas

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