Abstract
Concomitant plasma and serum tricyclic determinations were performed on 20 patients chronically administered imipramine (N = 10), amitriptyline (N = 10), desipramine (N = 10), and nortriptyline (N = 10). Plasma levels for these tricyclic antidepressants were significantly greater than the corresponding serum levels. Plasma-serum differences for the secondary amines (DMI/NT) were more than twice those for the tertiary amines (IMI/AMI). The authors thus suggest that clinicians and investigators specify the specific source of blood sample when assessing blood levels of the secondary tricyclic antidepressants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-224 |
| Number of pages | 8 |
| Journal | International Clinical Psychopharmacology |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1987 |
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)
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Coccaro, E. F., Adan, F., Allen, D., & Cooper, T. B. (1987). Plasma-serum differences in the assessment of tricyclic antidepressant blood levels. International Clinical Psychopharmacology, 2(3), 217-224. https://doi.org/10.1097/00004850-198707000-00004