Plasma-serum differences in the assessment of tricyclic antidepressant blood levels

Emil F. Coccaro, Federico Adan, David Allen, Thomas B. Cooper

Research output: Contribution to journalArticlepeer-review


Concomitant plasma and serum tricyclic determinations were performed on 20 patients chronically administered imipramine (N = 10), amitriptyline (N = 10), desipramine (N = 10), and nortriptyline (N = 10). Plasma levels for these tricyclic antidepressants were significantly greater than the corresponding serum levels. Plasma-serum differences for the secondary amines (DMI/NT) were more than twice those for the tertiary amines (IMI/AMI). The authors thus suggest that clinicians and investigators specify the specific source of blood sample when assessing blood levels of the secondary tricyclic antidepressants.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalInternational Clinical Psychopharmacology
Issue number3
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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