Plasma Lipid Levels at Diagnosis in Type 2 Diabetic Patients

J. M. Sosenko, Marta M Kato, R. Soto, R. B. Goldberg

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Plasma lipid measurements were obtained at the time that 545 subjects were screened for diabetes mellitus. Both the women and men diagnosed with diabetes had significantly higher triglyceride levels (p < 0.05) and lower high-density-lipoprotein cholesterol (HDL-cholesterol) levels (p < 0.05) than those with normal glucose tolerance. Low-density-lipoprotein cholesterol (LDL-cholesterol) levels were only higher in the diabetic women (p < 0.001). Differences in lipid values were diminished somewhat with allowances for the waist-hip ratio. HDL-cholesterol values were inversely related to fasting insulin levels in the normoglycaemic men and women (p < 0.01), but not in the diabetic individuals. Triglyceride levels were strongly positively related to insulin values in the normoglycaemic men and women (p < 0.001 for both), while associations tended to be smaller in the diabetic subjects. In 13 of the diabetic individuals who were not medicated for diabetes over a period of 17.5 ± 4.6 months, changes in HDL-cholesterol levels were positively related (p = 0.80, <0.001) and changes in tryglyceride levels inversely related (r = -0.70, p < 0.01) to changes in insulin values. These data indicate that at diagnosis Type 2 diabetic patients have an atherogenic lipid pattern that may be related in part to differences in adipose distribution. In addition, the data suggest that HDL-cholesterol is positively related and triglyceride inversely related to insulin action.

Original languageEnglish (US)
Pages (from-to)814-819
Number of pages6
JournalDiabetic Medicine
Volume10
Issue number9
DOIs
StatePublished - Nov 1993

Keywords

  • cholesterol
  • HDL-cholesterol
  • impaired glucose tolerance
  • triglyceride
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Fingerprint Dive into the research topics of 'Plasma Lipid Levels at Diagnosis in Type 2 Diabetic Patients'. Together they form a unique fingerprint.

  • Cite this