Plasma gonadotropins after administration of LH releasing hormone in patients with renal or hepatic failure

D. S. Schalch, D. Gonzalez-Barcena, A. J. Kastin, L. Landa, L. A. Lee, M. T. Zamora, Andrew V Schally

Research output: Contribution to journalArticle

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Abstract

The pituitary gonadotropin response to the administration of synthetic LH releasing hormone (LH RH) in 10 patients with renal failure and 5 patients with hepatic insufficiency was determined. The basal plasma LH and FSH levels were either normal or slightly elevated in both groups compared with the controls, but after the administration of LH RH, the peak levels (mean ± (SE) mIU/ml) of LH (72.0 ± 16.6) and FSH (18.7 ± 4.4) in the patients with renal failure, and of LH (61.5 ± 20.8) and FSH (13.2 ± 2.8) in patients with hepatic insufficiency, were not significantly different from those in 11 normal controls (LH, 75.6 ± 12.0; FSH, 12.4 ± 2.9). However, significant elevations in plasma gonadotropin levels persisted in these patients during the second and third hours after the administration of LH RH. These studies do not resolve the question of whether the prolonged elevation in plasma LH and FSH levels after LH RH administration is due to enhanced secretion, to a diminished rate of metabolic clearance of LH RH, and/or to the gonadotropins, or both. Evidence from this and previous studies suggest that there may be defects in the secretory functions of both the hypothalamus and pituitary gland in some of these patients.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume41
Issue number5
StatePublished - Dec 1 1975
Externally publishedYes

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Liver Failure
Gonadotropins
Gonadotropin-Releasing Hormone
Renal Insufficiency
Plasmas
Hepatic Insufficiency
Pituitary Gonadotropins
Metabolic Clearance Rate
Pituitary Gland
Hypothalamus
Defects

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Schalch, D. S., Gonzalez-Barcena, D., Kastin, A. J., Landa, L., Lee, L. A., Zamora, M. T., & Schally, A. V. (1975). Plasma gonadotropins after administration of LH releasing hormone in patients with renal or hepatic failure. Journal of Clinical Endocrinology and Metabolism, 41(5), 921-925.

Plasma gonadotropins after administration of LH releasing hormone in patients with renal or hepatic failure. / Schalch, D. S.; Gonzalez-Barcena, D.; Kastin, A. J.; Landa, L.; Lee, L. A.; Zamora, M. T.; Schally, Andrew V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 41, No. 5, 01.12.1975, p. 921-925.

Research output: Contribution to journalArticle

Schalch, DS, Gonzalez-Barcena, D, Kastin, AJ, Landa, L, Lee, LA, Zamora, MT & Schally, AV 1975, 'Plasma gonadotropins after administration of LH releasing hormone in patients with renal or hepatic failure', Journal of Clinical Endocrinology and Metabolism, vol. 41, no. 5, pp. 921-925.
Schalch DS, Gonzalez-Barcena D, Kastin AJ, Landa L, Lee LA, Zamora MT et al. Plasma gonadotropins after administration of LH releasing hormone in patients with renal or hepatic failure. Journal of Clinical Endocrinology and Metabolism. 1975 Dec 1;41(5):921-925.
Schalch, D. S. ; Gonzalez-Barcena, D. ; Kastin, A. J. ; Landa, L. ; Lee, L. A. ; Zamora, M. T. ; Schally, Andrew V. / Plasma gonadotropins after administration of LH releasing hormone in patients with renal or hepatic failure. In: Journal of Clinical Endocrinology and Metabolism. 1975 ; Vol. 41, No. 5. pp. 921-925.
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