Plasma fibronectin in medical ICU patients

M. T. O'Connell, D. M. Becker, B. W. Steele, G. S. Peterson, R. L. Hellman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Plasma fibronectin levels in 66 medical ICU (MICU) patients were measured daily. Mean values of initial levels were significantly higher in survivors (266 ± 14 mg/L) than nonsurvivors (179 ± 13 mg/L; p < .0003). There was extensive overlap between survivors and nonsurvivors. The clinical categories of sepsis, disseminated intravascular coagulation (DIC), adult respiratory distress syndrome (ARDS), and hepatic failure with GI bleeding were associated with low fibronectin levels. Within all diagnostic categories the mean initial fibronectin level of the survivors was higher than that of nonsurvivors. This difference was significant only in the septic group (p < .02). Patients with minimum fibronectin levels < 195 mg/L had a 65% mortality rate; patients with minimum levels ≥195 mg/L had a 17% mortality rate. Fibronectin, via its role in reticuloendothelial system (RES) function, may have a pathophysiologic role in a variety of medical illness.

Original languageEnglish (US)
Pages (from-to)479-482
Number of pages4
JournalCritical care medicine
Issue number6
StatePublished - 1984

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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