Plasma exchange in stiff-man syndrome

Sherry Shariatmadar, Thomas A. Noto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Stiff-man syndrome (STS) is a rare neurological disorder characterized by involuntary axial and proximal limb rigidity and continuous motor unit activity on electromyography (EMG). Autoantibodies to glutamic acid decarboxylase (GAD) present in 60% of the patients are implicated. We report on the use of plasma exchange (PE) in 2 patients with STS whose serum and cerebrospinal fluid were negative for GAD autoantibodies. One patient showed minimal clinical improvement following PE while the second reported subjective improvement, but not any different from that with medications. Based on the results of PE in our patients, it seems that those who are autoantibody negative are less likely to respond. Whether a more aggressive approach to PE will be beneficial remains speculative.

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalTherapeutic Apheresis
Volume5
Issue number1
DOIs
StatePublished - Mar 15 2001

Fingerprint

Stiff-Person Syndrome
Plasma Exchange
Autoantibodies
Glutamate Decarboxylase
Electromyography
Nervous System Diseases
Cerebrospinal Fluid
Motor Activity
Extremities
Serum

Keywords

  • Autoantibody
  • Continuous motor unit activity
  • Electromyography
  • Gamma aminobuteric acid
  • Glutamic acid decarboxylase
  • Stiff-man syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Plasma exchange in stiff-man syndrome. / Shariatmadar, Sherry; Noto, Thomas A.

In: Therapeutic Apheresis, Vol. 5, No. 1, 15.03.2001, p. 64-67.

Research output: Contribution to journalArticle

Shariatmadar, Sherry ; Noto, Thomas A. / Plasma exchange in stiff-man syndrome. In: Therapeutic Apheresis. 2001 ; Vol. 5, No. 1. pp. 64-67.
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