Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis

Mary Beth Dorr; Anita L. Nelson; Philip R. Mayer; Radhika P. Ranganath; Paul Michael Norris; Eileen C. Helzner; Richard A. Preston

doi:10.1016/j.fertnstert.2010.03.076

Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis

Mary Beth Dorr, Anita L. Nelson, Philip R. Mayer, Radhika P. Ranganath, Paul Michael Norris, Eileen C. Helzner, Richard A. Preston

Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this open-label, randomized, multiple-dose, two-treatment crossover study, 24 postmenopausal women with moderate to severe atrophic vaginitis received 0.3 mg conjugated estrogens daily for 14 days: 7 days orally (0.3 mg tablet) and 7 days vaginally (0.5 g cream). Steady-state plasma concentrations of E₂ and estrone were one-third lower after vaginal versus oral administration of conjugated estrogens.

Original language	English (US)
Pages (from-to)	2365-2368
Number of pages	4
Journal	Fertility and sterility
Volume	94
Issue number	6
DOIs	https://doi.org/10.1016/j.fertnstert.2010.03.076
State	Published - Nov 1 2010

Keywords

absorption
Conjugated estrogens
ET
pharmacokinetics
vaginal cream

ASJC Scopus subject areas

Obstetrics and Gynecology
Reproductive Medicine

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Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. / Dorr, Mary Beth; Nelson, Anita L.; Mayer, Philip R.; Ranganath, Radhika P.; Norris, Paul Michael; Helzner, Eileen C.; Preston, Richard A.

In: Fertility and sterility, Vol. 94, No. 6, 01.11.2010, p. 2365-2368.

Research output: Contribution to journal › Article › peer-review

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