Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis

Mary Beth Dorr, Anita L. Nelson, Philip R. Mayer, Radhika P. Ranganath, Paul M. Norris, Eileen C. Helzner, Richard A Preston

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

In this open-label, randomized, multiple-dose, two-treatment crossover study, 24 postmenopausal women with moderate to severe atrophic vaginitis received 0.3 mg conjugated estrogens daily for 14 days: 7 days orally (0.3 mg tablet) and 7 days vaginally (0.5 g cream). Steady-state plasma concentrations of E2 and estrone were one-third lower after vaginal versus oral administration of conjugated estrogens.

Original languageEnglish
Pages (from-to)2365-2368
Number of pages4
JournalFertility and Sterility
Volume94
Issue number6
DOIs
StatePublished - Nov 1 2010

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Atrophic Vaginitis
Intravaginal Administration
Conjugated (USP) Estrogens
Estrogens
Estrone
Cross-Over Studies
Tablets
Oral Administration
Therapeutics

Keywords

  • absorption
  • Conjugated estrogens
  • ET
  • pharmacokinetics
  • vaginal cream

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. / Dorr, Mary Beth; Nelson, Anita L.; Mayer, Philip R.; Ranganath, Radhika P.; Norris, Paul M.; Helzner, Eileen C.; Preston, Richard A.

In: Fertility and Sterility, Vol. 94, No. 6, 01.11.2010, p. 2365-2368.

Research output: Contribution to journal › Article

Dorr, MB, Nelson, AL, Mayer, PR, Ranganath, RP, Norris, PM, Helzner, EC & Preston, RA 2010, 'Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis', Fertility and Sterility, vol. 94, no. 6, pp. 2365-2368. https://doi.org/10.1016/j.fertnstert.2010.03.076
Dorr MB, Nelson AL, Mayer PR, Ranganath RP, Norris PM, Helzner EC et al. Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. Fertility and Sterility. 2010 Nov 1;94(6):2365-2368. https://doi.org/10.1016/j.fertnstert.2010.03.076
Dorr, Mary Beth ; Nelson, Anita L. ; Mayer, Philip R. ; Ranganath, Radhika P. ; Norris, Paul M. ; Helzner, Eileen C. ; Preston, Richard A. / Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. In: Fertility and Sterility. 2010 ; Vol. 94, No. 6. pp. 2365-2368.
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