Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis

Mary Beth Dorr, Anita L. Nelson, Philip R. Mayer, Radhika P. Ranganath, Paul M. Norris, Eileen C. Helzner, Richard A. Preston

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

In this open-label, randomized, multiple-dose, two-treatment crossover study, 24 postmenopausal women with moderate to severe atrophic vaginitis received 0.3 mg conjugated estrogens daily for 14 days: 7 days orally (0.3 mg tablet) and 7 days vaginally (0.5 g cream). Steady-state plasma concentrations of E2 and estrone were one-third lower after vaginal versus oral administration of conjugated estrogens.

Original languageEnglish (US)
Pages (from-to)2365-2368
Number of pages4
JournalFertility and sterility
Volume94
Issue number6
DOIs
StatePublished - Nov 1 2010

Keywords

  • absorption
  • Conjugated estrogens
  • ET
  • pharmacokinetics
  • vaginal cream

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis'. Together they form a unique fingerprint.

  • Cite this