Plasma amino acid patterns during supplemental intravenous nutrition of low-birth-weight infants

Carolyn Abitbol, Donita B. Feldman, Peter Ahmann, Daniel Rudman

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In 42 low-birth-weight infants (<1,200 gm), we have compared the effects of intravenous nutrition supplement versus conventional feedings on growth, morbidity, mortality, and plasma amino acid patterns. Despite similar total caloric intake in INS and control groups, weight gain was greater in the INS infants. The overall mortality rate did not differ in the two groups. Nonsurviving infants receiving INS lived longer (mean=30 days) than nonsurviving CON infants (mean=5 days). Complications were equally frequent in both group except that hyperglycemia occurred more often in infants receiving INS. The plasma aminogram of the LBW infant is described and compared to those of the full-term infant and adult. Hypoaminoacidemia was present at birth in the LBW infants, concentrations of glutamine, alanine, glycine, histidine, and ornithine being significantly (P<0.05) below FT values. During INS, elevations of threonine, serine, and methionine above FT values occurred. Glutamine remained subnormal despite INS. Recommendations for an INS solution more suitable for use in LBW infants are presented.

Original languageEnglish
Pages (from-to)766-772
Number of pages7
JournalThe Journal of pediatrics
Volume86
Issue number5
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Fingerprint

Low Birth Weight Infant
Amino Acids
Glutamine
Ornithine
Mortality
Threonine
Energy Intake
Histidine
Hyperglycemia
Alanine
Methionine
Glycine
Serine
Weight Gain
Parturition
Morbidity
Control Groups
Growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Plasma amino acid patterns during supplemental intravenous nutrition of low-birth-weight infants. / Abitbol, Carolyn; Feldman, Donita B.; Ahmann, Peter; Rudman, Daniel.

In: The Journal of pediatrics, Vol. 86, No. 5, 01.01.1975, p. 766-772.

Research output: Contribution to journalArticle

Abitbol, Carolyn ; Feldman, Donita B. ; Ahmann, Peter ; Rudman, Daniel. / Plasma amino acid patterns during supplemental intravenous nutrition of low-birth-weight infants. In: The Journal of pediatrics. 1975 ; Vol. 86, No. 5. pp. 766-772.
@article{8c1e52cc0fd148a4befe5a8b5b69cb4d,
title = "Plasma amino acid patterns during supplemental intravenous nutrition of low-birth-weight infants",
abstract = "In 42 low-birth-weight infants (<1,200 gm), we have compared the effects of intravenous nutrition supplement versus conventional feedings on growth, morbidity, mortality, and plasma amino acid patterns. Despite similar total caloric intake in INS and control groups, weight gain was greater in the INS infants. The overall mortality rate did not differ in the two groups. Nonsurviving infants receiving INS lived longer (mean=30 days) than nonsurviving CON infants (mean=5 days). Complications were equally frequent in both group except that hyperglycemia occurred more often in infants receiving INS. The plasma aminogram of the LBW infant is described and compared to those of the full-term infant and adult. Hypoaminoacidemia was present at birth in the LBW infants, concentrations of glutamine, alanine, glycine, histidine, and ornithine being significantly (P<0.05) below FT values. During INS, elevations of threonine, serine, and methionine above FT values occurred. Glutamine remained subnormal despite INS. Recommendations for an INS solution more suitable for use in LBW infants are presented.",
author = "Carolyn Abitbol and Feldman, {Donita B.} and Peter Ahmann and Daniel Rudman",
year = "1975",
month = "1",
day = "1",
doi = "10.1016/S0022-3476(75)80369-6",
language = "English",
volume = "86",
pages = "766--772",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Plasma amino acid patterns during supplemental intravenous nutrition of low-birth-weight infants

AU - Abitbol, Carolyn

AU - Feldman, Donita B.

AU - Ahmann, Peter

AU - Rudman, Daniel

PY - 1975/1/1

Y1 - 1975/1/1

N2 - In 42 low-birth-weight infants (<1,200 gm), we have compared the effects of intravenous nutrition supplement versus conventional feedings on growth, morbidity, mortality, and plasma amino acid patterns. Despite similar total caloric intake in INS and control groups, weight gain was greater in the INS infants. The overall mortality rate did not differ in the two groups. Nonsurviving infants receiving INS lived longer (mean=30 days) than nonsurviving CON infants (mean=5 days). Complications were equally frequent in both group except that hyperglycemia occurred more often in infants receiving INS. The plasma aminogram of the LBW infant is described and compared to those of the full-term infant and adult. Hypoaminoacidemia was present at birth in the LBW infants, concentrations of glutamine, alanine, glycine, histidine, and ornithine being significantly (P<0.05) below FT values. During INS, elevations of threonine, serine, and methionine above FT values occurred. Glutamine remained subnormal despite INS. Recommendations for an INS solution more suitable for use in LBW infants are presented.

AB - In 42 low-birth-weight infants (<1,200 gm), we have compared the effects of intravenous nutrition supplement versus conventional feedings on growth, morbidity, mortality, and plasma amino acid patterns. Despite similar total caloric intake in INS and control groups, weight gain was greater in the INS infants. The overall mortality rate did not differ in the two groups. Nonsurviving infants receiving INS lived longer (mean=30 days) than nonsurviving CON infants (mean=5 days). Complications were equally frequent in both group except that hyperglycemia occurred more often in infants receiving INS. The plasma aminogram of the LBW infant is described and compared to those of the full-term infant and adult. Hypoaminoacidemia was present at birth in the LBW infants, concentrations of glutamine, alanine, glycine, histidine, and ornithine being significantly (P<0.05) below FT values. During INS, elevations of threonine, serine, and methionine above FT values occurred. Glutamine remained subnormal despite INS. Recommendations for an INS solution more suitable for use in LBW infants are presented.

UR - http://www.scopus.com/inward/record.url?scp=0016768351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016768351&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(75)80369-6

DO - 10.1016/S0022-3476(75)80369-6

M3 - Article

VL - 86

SP - 766

EP - 772

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 5

ER -