Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity

Alice S. Ryan, Dora Berman-Weinberg, Barbara J. Nicklas, Madhur Sinha, Ronald L. Gingerich, Grady S. Meneilly, Josephine M. Egan, Dariush Elahi

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

OBJECTIVE - The purpose of this study was to determine the relationships between plasma adiponectin and leptin levels, total and central obesity, and glucose utilization across the adult age span. RESEARCH DESIGN AND METHODS - We studied 148 women aged 18-81 years with a BMI range of 17.2-44.3 kg/m 2. Total percent body fat was determined by dual-energy X-ray absorptiometry and abdominal fat by computed tomography. Glucose tolerance in nontype 2 diabetic volunteers was determined with an oral glucose tolerance test. Glucose utilization (M) was measured during the last 60 min of hyperinsulinemic-euglycemic clamps (240 pmol · m-2 · min-1). Plasma adiponectin levels were measured by radioimmunoassay. The women were separated into three age-groups: young, middle, and old (<40, 40-59, and ≥60 years, respectively), as well as by glucose tolerance status. RESULTS - Adiponectin concentrations did not differ by age-groups. There were significant age effects for BMI, percent body fat, visceral fat, subcutaneous abdominal fat, VO2max, and M. Adiponectin levels were lower in the prediabetic women (n = 18) than in the normal glucose-tolerant women (n = 108) and the women with type 2 diabetes (n = 22) (both P < 0.05). Univariate correlations revealed significant negative relationships between plasma adiponectin levels and BMI, percent body fat, visceral fat, subcutaneous abdominal fat, fasting leptin, and fasting insulin and positive relationship with M (all P < 0.05). In a multiple stepwise regression model to predict adiponectin, only M remained in the model at P < 0.001. Multivariate analyses revealed a significant relation for M as a function of adiponectin, insulin, and VO2max. CONCLUSIONS - The data suggest that plasma adiponectin does not change with age but levels are negatively associated with percent body fat, visceral fat, subcutaneous abdominal fat, insulin, and leptin levels in women. Adiponectin is positively associated with M across the age span in women.

Original languageEnglish
Pages (from-to)2383-2388
Number of pages6
JournalDiabetes Care
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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Adiponectin
Leptin
Body Composition
Obesity
Glucose
Abdominal Subcutaneous Fat
Intra-Abdominal Fat
Adipose Tissue
Insulin
Fasting
Age Groups
Abdominal Fat
Glucose Clamp Technique
Abdominal Obesity
Photon Absorptiometry
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Radioimmunoassay
Volunteers
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. / Ryan, Alice S.; Berman-Weinberg, Dora; Nicklas, Barbara J.; Sinha, Madhur; Gingerich, Ronald L.; Meneilly, Grady S.; Egan, Josephine M.; Elahi, Dariush.

In: Diabetes Care, Vol. 26, No. 8, 01.08.2003, p. 2383-2388.

Research output: Contribution to journalArticle

Ryan, Alice S. ; Berman-Weinberg, Dora ; Nicklas, Barbara J. ; Sinha, Madhur ; Gingerich, Ronald L. ; Meneilly, Grady S. ; Egan, Josephine M. ; Elahi, Dariush. / Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. In: Diabetes Care. 2003 ; Vol. 26, No. 8. pp. 2383-2388.
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AU - Sinha, Madhur

AU - Gingerich, Ronald L.

AU - Meneilly, Grady S.

AU - Egan, Josephine M.

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