Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance: A multicenter study

M. W. Groch, E. G. Depuey, A. C. Belzberg, W. D. Erwin, M. Kamran, C. A. Barnett, Robert Hendel, S. M. Spies, A. Ali, R. C. Marshall

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Gated blood-pool SPECT (GBPS), inherently 3-dimensional (3D), has the potential to replace planar equilibrium radionuclide angiography (ERNA) for computation of left ventricular ejection fraction (LVEF), analysis of regional wall motion (RWM), and analysis of right heart function. The purpose of this study was to compare GBPS and ERNA for the assessment of ventricular function in a large, multicenter cohort of patients. Methods: One hundred seventy-eight patients referred in the usual manner for nuclear medicine studies underwent ERNA followed by GBPS. Each clinical site followed a GBPS acquisition protocol that included 180° rotation, a 64 by 64 matrix, and 64 or 32 views using single- or double-head cameras. Transverse GBPS images were reconstructed with a Butterworth filter (cutoff frequency, 0.45-0.55 Nyquist; order, 7), and short-axis images were created. All GBPS studies were processed with a new GBPS program, and LVEF was computed from the isolated left ventricular chamber and compared with standard ERNA LVEF. Reproducibility of GBPS LVEF was evaluated, and right ventricular ejection fraction (RVEF) was computed in a subset of patients (n = 33). Using GBPS, RWM and image quality from 3D surface-shaded and volume-rendered cine displays were evaluated qualitatively in a subset of patients (n = 30). Results: The correlation between GBPS LVEF and planar LVEF was excellent (r = 0.92). Mean LVEF was 62.2% for GBPS and 54.1% for ERNA. The line of linear regression was GBPS LVEF = (1.04 x ERNA LVEF) + 6.1. Bland-Altman plotting revealed an increasing bias in GBPS LVEF with increasing LVEF (Y = 0.13x + 0.61; r = 0.30; mean difference = 8.1% ± 7.0%). Interoperator reproducibility of GBPS LVEF was good (r = 0.92). RVEF values averaged 59.8%. RWM assessment using 3D cine display was enhanced in 27% of the studies, equivalent in 67%, and inferior in 7%. Conclusion: GBPS LVEF was reproducible and correlated well with planar ERNA. GBPS LVEF values were somewhat higher than planar ERNA, likely because of the exclusion of the left atrium.

Original languageEnglish
Pages (from-to)1773-1779
Number of pages7
JournalJournal of Nuclear Medicine
Volume42
Issue number12
StatePublished - Dec 1 2001
Externally publishedYes

Fingerprint

Gated Blood-Pool Imaging
Single-Photon Emission-Computed Tomography
Stroke Volume
Multicenter Studies
Ventricular Function

Keywords

  • Gated blood-pool imaging
  • Gated SPECT
  • Left ventricular ejection fraction

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Groch, M. W., Depuey, E. G., Belzberg, A. C., Erwin, W. D., Kamran, M., Barnett, C. A., ... Marshall, R. C. (2001). Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance: A multicenter study. Journal of Nuclear Medicine, 42(12), 1773-1779.

Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance : A multicenter study. / Groch, M. W.; Depuey, E. G.; Belzberg, A. C.; Erwin, W. D.; Kamran, M.; Barnett, C. A.; Hendel, Robert; Spies, S. M.; Ali, A.; Marshall, R. C.

In: Journal of Nuclear Medicine, Vol. 42, No. 12, 01.12.2001, p. 1773-1779.

Research output: Contribution to journalArticle

Groch, MW, Depuey, EG, Belzberg, AC, Erwin, WD, Kamran, M, Barnett, CA, Hendel, R, Spies, SM, Ali, A & Marshall, RC 2001, 'Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance: A multicenter study', Journal of Nuclear Medicine, vol. 42, no. 12, pp. 1773-1779.
Groch MW, Depuey EG, Belzberg AC, Erwin WD, Kamran M, Barnett CA et al. Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance: A multicenter study. Journal of Nuclear Medicine. 2001 Dec 1;42(12):1773-1779.
Groch, M. W. ; Depuey, E. G. ; Belzberg, A. C. ; Erwin, W. D. ; Kamran, M. ; Barnett, C. A. ; Hendel, Robert ; Spies, S. M. ; Ali, A. ; Marshall, R. C. / Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance : A multicenter study. In: Journal of Nuclear Medicine. 2001 ; Vol. 42, No. 12. pp. 1773-1779.
@article{182d151fae34432ebc60486045aeadcf,
title = "Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance: A multicenter study",
abstract = "Gated blood-pool SPECT (GBPS), inherently 3-dimensional (3D), has the potential to replace planar equilibrium radionuclide angiography (ERNA) for computation of left ventricular ejection fraction (LVEF), analysis of regional wall motion (RWM), and analysis of right heart function. The purpose of this study was to compare GBPS and ERNA for the assessment of ventricular function in a large, multicenter cohort of patients. Methods: One hundred seventy-eight patients referred in the usual manner for nuclear medicine studies underwent ERNA followed by GBPS. Each clinical site followed a GBPS acquisition protocol that included 180° rotation, a 64 by 64 matrix, and 64 or 32 views using single- or double-head cameras. Transverse GBPS images were reconstructed with a Butterworth filter (cutoff frequency, 0.45-0.55 Nyquist; order, 7), and short-axis images were created. All GBPS studies were processed with a new GBPS program, and LVEF was computed from the isolated left ventricular chamber and compared with standard ERNA LVEF. Reproducibility of GBPS LVEF was evaluated, and right ventricular ejection fraction (RVEF) was computed in a subset of patients (n = 33). Using GBPS, RWM and image quality from 3D surface-shaded and volume-rendered cine displays were evaluated qualitatively in a subset of patients (n = 30). Results: The correlation between GBPS LVEF and planar LVEF was excellent (r = 0.92). Mean LVEF was 62.2{\%} for GBPS and 54.1{\%} for ERNA. The line of linear regression was GBPS LVEF = (1.04 x ERNA LVEF) + 6.1. Bland-Altman plotting revealed an increasing bias in GBPS LVEF with increasing LVEF (Y = 0.13x + 0.61; r = 0.30; mean difference = 8.1{\%} ± 7.0{\%}). Interoperator reproducibility of GBPS LVEF was good (r = 0.92). RVEF values averaged 59.8{\%}. RWM assessment using 3D cine display was enhanced in 27{\%} of the studies, equivalent in 67{\%}, and inferior in 7{\%}. Conclusion: GBPS LVEF was reproducible and correlated well with planar ERNA. GBPS LVEF values were somewhat higher than planar ERNA, likely because of the exclusion of the left atrium.",
keywords = "Gated blood-pool imaging, Gated SPECT, Left ventricular ejection fraction",
author = "Groch, {M. W.} and Depuey, {E. G.} and Belzberg, {A. C.} and Erwin, {W. D.} and M. Kamran and Barnett, {C. A.} and Robert Hendel and Spies, {S. M.} and A. Ali and Marshall, {R. C.}",
year = "2001",
month = "12",
day = "1",
language = "English",
volume = "42",
pages = "1773--1779",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "12",

}

TY - JOUR

T1 - Planar imaging versus gated blood-pool SPECT for the assessment of ventricular performance

T2 - A multicenter study

AU - Groch, M. W.

AU - Depuey, E. G.

AU - Belzberg, A. C.

AU - Erwin, W. D.

AU - Kamran, M.

AU - Barnett, C. A.

AU - Hendel, Robert

AU - Spies, S. M.

AU - Ali, A.

AU - Marshall, R. C.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Gated blood-pool SPECT (GBPS), inherently 3-dimensional (3D), has the potential to replace planar equilibrium radionuclide angiography (ERNA) for computation of left ventricular ejection fraction (LVEF), analysis of regional wall motion (RWM), and analysis of right heart function. The purpose of this study was to compare GBPS and ERNA for the assessment of ventricular function in a large, multicenter cohort of patients. Methods: One hundred seventy-eight patients referred in the usual manner for nuclear medicine studies underwent ERNA followed by GBPS. Each clinical site followed a GBPS acquisition protocol that included 180° rotation, a 64 by 64 matrix, and 64 or 32 views using single- or double-head cameras. Transverse GBPS images were reconstructed with a Butterworth filter (cutoff frequency, 0.45-0.55 Nyquist; order, 7), and short-axis images were created. All GBPS studies were processed with a new GBPS program, and LVEF was computed from the isolated left ventricular chamber and compared with standard ERNA LVEF. Reproducibility of GBPS LVEF was evaluated, and right ventricular ejection fraction (RVEF) was computed in a subset of patients (n = 33). Using GBPS, RWM and image quality from 3D surface-shaded and volume-rendered cine displays were evaluated qualitatively in a subset of patients (n = 30). Results: The correlation between GBPS LVEF and planar LVEF was excellent (r = 0.92). Mean LVEF was 62.2% for GBPS and 54.1% for ERNA. The line of linear regression was GBPS LVEF = (1.04 x ERNA LVEF) + 6.1. Bland-Altman plotting revealed an increasing bias in GBPS LVEF with increasing LVEF (Y = 0.13x + 0.61; r = 0.30; mean difference = 8.1% ± 7.0%). Interoperator reproducibility of GBPS LVEF was good (r = 0.92). RVEF values averaged 59.8%. RWM assessment using 3D cine display was enhanced in 27% of the studies, equivalent in 67%, and inferior in 7%. Conclusion: GBPS LVEF was reproducible and correlated well with planar ERNA. GBPS LVEF values were somewhat higher than planar ERNA, likely because of the exclusion of the left atrium.

AB - Gated blood-pool SPECT (GBPS), inherently 3-dimensional (3D), has the potential to replace planar equilibrium radionuclide angiography (ERNA) for computation of left ventricular ejection fraction (LVEF), analysis of regional wall motion (RWM), and analysis of right heart function. The purpose of this study was to compare GBPS and ERNA for the assessment of ventricular function in a large, multicenter cohort of patients. Methods: One hundred seventy-eight patients referred in the usual manner for nuclear medicine studies underwent ERNA followed by GBPS. Each clinical site followed a GBPS acquisition protocol that included 180° rotation, a 64 by 64 matrix, and 64 or 32 views using single- or double-head cameras. Transverse GBPS images were reconstructed with a Butterworth filter (cutoff frequency, 0.45-0.55 Nyquist; order, 7), and short-axis images were created. All GBPS studies were processed with a new GBPS program, and LVEF was computed from the isolated left ventricular chamber and compared with standard ERNA LVEF. Reproducibility of GBPS LVEF was evaluated, and right ventricular ejection fraction (RVEF) was computed in a subset of patients (n = 33). Using GBPS, RWM and image quality from 3D surface-shaded and volume-rendered cine displays were evaluated qualitatively in a subset of patients (n = 30). Results: The correlation between GBPS LVEF and planar LVEF was excellent (r = 0.92). Mean LVEF was 62.2% for GBPS and 54.1% for ERNA. The line of linear regression was GBPS LVEF = (1.04 x ERNA LVEF) + 6.1. Bland-Altman plotting revealed an increasing bias in GBPS LVEF with increasing LVEF (Y = 0.13x + 0.61; r = 0.30; mean difference = 8.1% ± 7.0%). Interoperator reproducibility of GBPS LVEF was good (r = 0.92). RVEF values averaged 59.8%. RWM assessment using 3D cine display was enhanced in 27% of the studies, equivalent in 67%, and inferior in 7%. Conclusion: GBPS LVEF was reproducible and correlated well with planar ERNA. GBPS LVEF values were somewhat higher than planar ERNA, likely because of the exclusion of the left atrium.

KW - Gated blood-pool imaging

KW - Gated SPECT

KW - Left ventricular ejection fraction

UR - http://www.scopus.com/inward/record.url?scp=0035666391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035666391&partnerID=8YFLogxK

M3 - Article

C2 - 11752072

AN - SCOPUS:0035666391

VL - 42

SP - 1773

EP - 1779

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 12

ER -