Placental protein 5 in gestational trophoblastic disease: Localization and circulating levels

Andrew D. Nisbet, Roy D. Bremner, Charles H W Horne, Doris Brooker, Leo B. Twiggs, Takashi Okagaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

With the use of an indirect immunoperoxidase technique (peroxidase-antiperoxidase) placental protein 5 (PP5) has been shown to be present in a high percentage of gestational trophoblastic tumors, especially the better differentiated ones. By sensitive radioimmunoassay, PP5 has further been found to be present in sera from patients with persistent gestational trophoblastic disease but not to the same frequency or extent as human chorionic gonadotropin. The only finding of clinical importance was the association in one case of high levels of PP5 and concurrent intravascular coagulation.

Original languageEnglish
Pages (from-to)396-401
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume144
Issue number4
StatePublished - Oct 15 1982
Externally publishedYes

Fingerprint

Gestational Trophoblastic Disease
Trophoblastic Neoplasms
Chorionic Gonadotropin
Immunoenzyme Techniques
Peroxidase
Radioimmunoassay
Serum
tissue-factor-pathway inhibitor 2

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Nisbet, A. D., Bremner, R. D., Horne, C. H. W., Brooker, D., Twiggs, L. B., & Okagaki, T. (1982). Placental protein 5 in gestational trophoblastic disease: Localization and circulating levels. American Journal of Obstetrics and Gynecology, 144(4), 396-401.

Placental protein 5 in gestational trophoblastic disease : Localization and circulating levels. / Nisbet, Andrew D.; Bremner, Roy D.; Horne, Charles H W; Brooker, Doris; Twiggs, Leo B.; Okagaki, Takashi.

In: American Journal of Obstetrics and Gynecology, Vol. 144, No. 4, 15.10.1982, p. 396-401.

Research output: Contribution to journalArticle

Nisbet, AD, Bremner, RD, Horne, CHW, Brooker, D, Twiggs, LB & Okagaki, T 1982, 'Placental protein 5 in gestational trophoblastic disease: Localization and circulating levels', American Journal of Obstetrics and Gynecology, vol. 144, no. 4, pp. 396-401.
Nisbet AD, Bremner RD, Horne CHW, Brooker D, Twiggs LB, Okagaki T. Placental protein 5 in gestational trophoblastic disease: Localization and circulating levels. American Journal of Obstetrics and Gynecology. 1982 Oct 15;144(4):396-401.
Nisbet, Andrew D. ; Bremner, Roy D. ; Horne, Charles H W ; Brooker, Doris ; Twiggs, Leo B. ; Okagaki, Takashi. / Placental protein 5 in gestational trophoblastic disease : Localization and circulating levels. In: American Journal of Obstetrics and Gynecology. 1982 ; Vol. 144, No. 4. pp. 396-401.
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