Placental passage of tricyclic antidepressants

Ada M. Loughhead, Zachary N. Stowe, Donald J Newport, James C. Ritchie, C. Lindsay DeVane, Michael J. Owens

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited investigations that have sought to quantify fetal exposure. Methods: Maternal and umbilical cord sera were collected at delivery from ten women taking nortriptyline and seven taking clomipramine. Placental passage was calculated as the ratio of umbilical cord to maternal serum concentration. Obstetrical outcome data were gathered from subjects at delivery. Results: The placental passage ratio of nortriptyline and its active metabolite, cis-10-hydroxynortriptyline, were .68 ± .40, 1.40 ± 2.40, respectively. Clomipramine and desmethylclomipramine ratios were .60 ± .50, .80 ± .60. Obstetrical complications, such as pre-term delivery and pregnancy induced hypertension, were increased compared to the national average. Conclusions: The in vivo ratios of umbilical cord to maternal serum drug concentrations demonstrate considerable fetal exposure and differ greatly from previous results utilizing ex vivo perfusion.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalBiological Psychiatry
Volume59
Issue number3
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Fingerprint

Tricyclic Antidepressive Agents
Umbilical Cord
Nortriptyline
Clomipramine
Mothers
Serum
Pregnancy Induced Hypertension
Antidepressive Agents
Perfusion
Pregnancy
Pharmaceutical Preparations

Keywords

  • Antidepressants
  • Clomipramine
  • Nortriptyline
  • Placental passage
  • Pregnancy

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Loughhead, A. M., Stowe, Z. N., Newport, D. J., Ritchie, J. C., DeVane, C. L., & Owens, M. J. (2006). Placental passage of tricyclic antidepressants. Biological Psychiatry, 59(3), 287-290. https://doi.org/10.1016/j.biopsych.2005.06.040

Placental passage of tricyclic antidepressants. / Loughhead, Ada M.; Stowe, Zachary N.; Newport, Donald J; Ritchie, James C.; DeVane, C. Lindsay; Owens, Michael J.

In: Biological Psychiatry, Vol. 59, No. 3, 01.02.2006, p. 287-290.

Research output: Contribution to journalArticle

Loughhead, AM, Stowe, ZN, Newport, DJ, Ritchie, JC, DeVane, CL & Owens, MJ 2006, 'Placental passage of tricyclic antidepressants', Biological Psychiatry, vol. 59, no. 3, pp. 287-290. https://doi.org/10.1016/j.biopsych.2005.06.040
Loughhead AM, Stowe ZN, Newport DJ, Ritchie JC, DeVane CL, Owens MJ. Placental passage of tricyclic antidepressants. Biological Psychiatry. 2006 Feb 1;59(3):287-290. https://doi.org/10.1016/j.biopsych.2005.06.040
Loughhead, Ada M. ; Stowe, Zachary N. ; Newport, Donald J ; Ritchie, James C. ; DeVane, C. Lindsay ; Owens, Michael J. / Placental passage of tricyclic antidepressants. In: Biological Psychiatry. 2006 ; Vol. 59, No. 3. pp. 287-290.
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