Placental intravillous accumulation of sulfated mucosubstances. A reevaluation of so-called hydropic degeneration of villi

S. Suster, M. J. Robinson

Research output: Contribution to journalArticle

Abstract

A histochemical study was performed on 46 placentas showing so-called hydropic degeneration of villi. The 46 cases included early abortuses (35 cases), incomplete moles (four cases), and complete hydatidiform moles (seven cases). All the specimens showed diffuse, positive staining of the distended villous stroma with alcian blue at pH 1.2 and 2.5 in the areas containing 'hydropic changes.' The alcian blue positivity was abolished following digestion with hyaluronidase. These findings indicate that so-called 'hydropic degeneration of villi' represents an intravillous accumulation of strongly sulfated mucosubstances rather than the result of the accumulation of water. The intravillous accumulation of mucosubstances most likely represents a nonspecific stromal reaction of the connective tissue of the placenta to a variety of noxious stimuli. This finding may have some bearing on the interpretation of the physiologic mechanisms involved in placental villous distention, which has been largely centered in the past on the premise that the villous swelling was related to hemodynamic alterations caused by the accumulation of water.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalAnnals of Clinical and Laboratory Science
Volume22
Issue number3
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Alcian Blue
Edema
Bearings (structural)
Placenta
Hyaluronoglucosaminidase
Water
Hemodynamics
Swelling
Hydatidiform Mole
Tissue
Connective Tissue
Digestion
Staining and Labeling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry

Cite this

Placental intravillous accumulation of sulfated mucosubstances. A reevaluation of so-called hydropic degeneration of villi. / Suster, S.; Robinson, M. J.

In: Annals of Clinical and Laboratory Science, Vol. 22, No. 3, 01.01.1992, p. 175-181.

Research output: Contribution to journalArticle

@article{5e0f5fbd242244a49bc0b5dbb3f52021,
title = "Placental intravillous accumulation of sulfated mucosubstances. A reevaluation of so-called hydropic degeneration of villi",
abstract = "A histochemical study was performed on 46 placentas showing so-called hydropic degeneration of villi. The 46 cases included early abortuses (35 cases), incomplete moles (four cases), and complete hydatidiform moles (seven cases). All the specimens showed diffuse, positive staining of the distended villous stroma with alcian blue at pH 1.2 and 2.5 in the areas containing 'hydropic changes.' The alcian blue positivity was abolished following digestion with hyaluronidase. These findings indicate that so-called 'hydropic degeneration of villi' represents an intravillous accumulation of strongly sulfated mucosubstances rather than the result of the accumulation of water. The intravillous accumulation of mucosubstances most likely represents a nonspecific stromal reaction of the connective tissue of the placenta to a variety of noxious stimuli. This finding may have some bearing on the interpretation of the physiologic mechanisms involved in placental villous distention, which has been largely centered in the past on the premise that the villous swelling was related to hemodynamic alterations caused by the accumulation of water.",
author = "S. Suster and Robinson, {M. J.}",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "22",
pages = "175--181",
journal = "Annals of Clinical and Laboratory Science",
issn = "0091-7370",
publisher = "Association of Clinical Scientists",
number = "3",

}

TY - JOUR

T1 - Placental intravillous accumulation of sulfated mucosubstances. A reevaluation of so-called hydropic degeneration of villi

AU - Suster, S.

AU - Robinson, M. J.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A histochemical study was performed on 46 placentas showing so-called hydropic degeneration of villi. The 46 cases included early abortuses (35 cases), incomplete moles (four cases), and complete hydatidiform moles (seven cases). All the specimens showed diffuse, positive staining of the distended villous stroma with alcian blue at pH 1.2 and 2.5 in the areas containing 'hydropic changes.' The alcian blue positivity was abolished following digestion with hyaluronidase. These findings indicate that so-called 'hydropic degeneration of villi' represents an intravillous accumulation of strongly sulfated mucosubstances rather than the result of the accumulation of water. The intravillous accumulation of mucosubstances most likely represents a nonspecific stromal reaction of the connective tissue of the placenta to a variety of noxious stimuli. This finding may have some bearing on the interpretation of the physiologic mechanisms involved in placental villous distention, which has been largely centered in the past on the premise that the villous swelling was related to hemodynamic alterations caused by the accumulation of water.

AB - A histochemical study was performed on 46 placentas showing so-called hydropic degeneration of villi. The 46 cases included early abortuses (35 cases), incomplete moles (four cases), and complete hydatidiform moles (seven cases). All the specimens showed diffuse, positive staining of the distended villous stroma with alcian blue at pH 1.2 and 2.5 in the areas containing 'hydropic changes.' The alcian blue positivity was abolished following digestion with hyaluronidase. These findings indicate that so-called 'hydropic degeneration of villi' represents an intravillous accumulation of strongly sulfated mucosubstances rather than the result of the accumulation of water. The intravillous accumulation of mucosubstances most likely represents a nonspecific stromal reaction of the connective tissue of the placenta to a variety of noxious stimuli. This finding may have some bearing on the interpretation of the physiologic mechanisms involved in placental villous distention, which has been largely centered in the past on the premise that the villous swelling was related to hemodynamic alterations caused by the accumulation of water.

UR - http://www.scopus.com/inward/record.url?scp=0026596220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026596220&partnerID=8YFLogxK

M3 - Article

C2 - 1380222

AN - SCOPUS:0026596220

VL - 22

SP - 175

EP - 181

JO - Annals of Clinical and Laboratory Science

JF - Annals of Clinical and Laboratory Science

SN - 0091-7370

IS - 3

ER -