PKR, apoptosis and cancer

Rosemary Jagus, Bhavesh Joshi, Glen N Barber

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

The double-stranded (ds) RNA-regulated serine/threonine protein kinase, PKR, is an interferon-inducible enzyme of widespread occurrence in mammalian cells. PKR is activated by dsRNA via a mechanism involving autophosphorylation. Once activated, the enzyme phosphorylates the α-subunit of protein synthesis initiation factor eIF2, thereby inhibiting translation. Accumulating data suggest that PKR has additional substrates, and that the kinase may also regulate gene transcription and signal transduction pathways. Although PKR plays an important role in mediating the antiviral effects of interferons, PKR is also implicated in regulating cell proliferation in uninfected cells and may have a tumor suppressor function under normal conditions. Studies of human malignancies and tumor cell lines suggest that, in general, patients bearing tumors with a higher PKR content have a more favorable prognosis. However, in human breast carcinoma cells, dysregulation of PKR may be associated with the establishment or maintenance of the transformed state.

Original languageEnglish
Pages (from-to)123-138
Number of pages16
JournalInternational Journal of Biochemistry and Cell Biology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Tumors
Cells
Apoptosis
Interferons
Bearings (structural)
eIF-2 Kinase
Neoplasms
Peptide Initiation Factors
Signal transduction
Double-Stranded RNA
Protein-Serine-Threonine Kinases
Protein Subunits
Cell proliferation
Enzymes
Transcription
Tumor Cell Line
Antiviral Agents
Signal Transduction
Phosphotransferases
Genes

Keywords

  • Apoptosis
  • Breast cancer
  • eIF2α
  • PKR
  • Translational regulation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

PKR, apoptosis and cancer. / Jagus, Rosemary; Joshi, Bhavesh; Barber, Glen N.

In: International Journal of Biochemistry and Cell Biology, Vol. 31, No. 1, 01.01.1999, p. 123-138.

Research output: Contribution to journalArticle

Jagus, Rosemary ; Joshi, Bhavesh ; Barber, Glen N. / PKR, apoptosis and cancer. In: International Journal of Biochemistry and Cell Biology. 1999 ; Vol. 31, No. 1. pp. 123-138.
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