PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells

Lena Eliasson, Erik Renström, Carina Ämmälä, Per Olof Berggren, Alejandro M. Bertorello, Krister Bokvist, Alexander Chibalin, Jude T. Deeney, Peter R. Flatt, Jakob Gäbel, Jesper Gromada, Olof Larsson, Per Lindström, Christopher J. Rhodes, Patrik Rorsman

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185 Scopus citations

Abstract

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic β cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (K(ATP) channels) in the β cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane K(ATP) channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.

Original languageEnglish (US)
Pages (from-to)813-815
Number of pages3
JournalScience
Volume271
Issue number5250
DOIs
StatePublished - Feb 9 1996

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    Eliasson, L., Renström, E., Ämmälä, C., Berggren, P. O., Bertorello, A. M., Bokvist, K., Chibalin, A., Deeney, J. T., Flatt, P. R., Gäbel, J., Gromada, J., Larsson, O., Lindström, P., Rhodes, C. J., & Rorsman, P. (1996). PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells. Science, 271(5250), 813-815. https://doi.org/10.1126/science.271.5250.813