Pituitary size in depression

K. Ranga Rama Krishnan, P. Murali Doraiswamy, Scott N. Lurie, Gary S. Figiel, Mustafa M. Husain, Orest B. Boyko, Everett H. Ellinwood, Charles Nemeroff

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume72
Issue number2
StatePublished - Feb 1 1991
Externally publishedYes

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Pituitary Gland
Magnetic resonance
Magnetic Resonance Spectroscopy
Demonstrations

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Krishnan, K. R. R., Doraiswamy, P. M., Lurie, S. N., Figiel, G. S., Husain, M. M., Boyko, O. B., ... Nemeroff, C. (1991). Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism, 72(2), 256-259.

Pituitary size in depression. / Krishnan, K. Ranga Rama; Doraiswamy, P. Murali; Lurie, Scott N.; Figiel, Gary S.; Husain, Mustafa M.; Boyko, Orest B.; Ellinwood, Everett H.; Nemeroff, Charles.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 72, No. 2, 01.02.1991, p. 256-259.

Research output: Contribution to journalArticle

Krishnan, KRR, Doraiswamy, PM, Lurie, SN, Figiel, GS, Husain, MM, Boyko, OB, Ellinwood, EH & Nemeroff, C 1991, 'Pituitary size in depression', Journal of Clinical Endocrinology and Metabolism, vol. 72, no. 2, pp. 256-259.
Krishnan KRR, Doraiswamy PM, Lurie SN, Figiel GS, Husain MM, Boyko OB et al. Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism. 1991 Feb 1;72(2):256-259.
Krishnan, K. Ranga Rama ; Doraiswamy, P. Murali ; Lurie, Scott N. ; Figiel, Gary S. ; Husain, Mustafa M. ; Boyko, Orest B. ; Ellinwood, Everett H. ; Nemeroff, Charles. / Pituitary size in depression. In: Journal of Clinical Endocrinology and Metabolism. 1991 ; Vol. 72, No. 2. pp. 256-259.
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