Pituitary responsiveness to synthetic luteinizing hormone-releasing hormone during pregnancy: Effect on follicle-stimulating hormone secretion

Arturo Zárate, Elías S. Canales, Jorge Soria, Carlos MacGregor, Pedro J. Maneiro, Andrew V. Schally

Research output: Contribution to journalArticle

20 Scopus citations


Thirteen pregnant women were given synthetic luteinizing hormone-releasing hormone (LH-RH) by a single intravenous injection. Serum concentrations of follicle-stimulating hormone (FSH) were measured by radioimmunoassay. A significant rise in FSH was found after LH-RH administration in 10 of the 13 patients; however the response was very variable in each case. The maximum increase in the serum levels of FSH above the base line remained constant with the advancement of pregnancy. The present study confirms that the pituitary gland responds to LH-RH administration with the secretion of FSH despite the high levels of sex steroid and chorionic gonadotropin during pregnancy.

Original languageEnglish (US)
Pages (from-to)1121-1123
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Issue number8
StatePublished - Aug 15 1973


ASJC Scopus subject areas

  • Obstetrics and Gynecology

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