Pituitary response to synthetic luteinizing hormone- releasing hormone in prader-willi syndrome, prepubertal and pubertal children

A. Zàrate; J. Soria; E. S. Canales; A. J. Kastin; A. V. Schally; R. Guzmàn Toledano

doi:10.1159/000122217

Pituitary response to synthetic luteinizing hormone- releasing hormone in prader-willi syndrome, prepubertal and pubertal children

A. Zàrate, J. Soria, E. S. Canales, A. J. Kastin, A. V. Schally, R. Guzmàn Toledano

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Pituitary responsiveness to the intravenous injection of synthetic luteinizing hormone releasing hormone (LHRH) was studied in a female patient with Prader Willi syndrome and the response was compared with that obtained in prepubertal and pubertal subjects. LHRH caused the release of minimal amounts of LH and FSH in Prader Willi syndrome as compared with the LHRH response of prepubertal and pubertal female children. From these observations it is concluded that hypogonadotropism in Prader Willi syndrome may be due to a hypothalamic lesion associated with impaired or limited pituitary responsiveness.

Original language	English (US)
Pages (from-to)	321-326
Number of pages	6
Journal	Neuroendocrinology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1159/000122217
State	Published - Jan 1 1973
Externally published	Yes

Keywords

LH-RH
Pituitary
Prader-willi syndrome
Puberty

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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title = "Pituitary response to synthetic luteinizing hormone- releasing hormone in prader-willi syndrome, prepubertal and pubertal children",

abstract = "Pituitary responsiveness to the intravenous injection of synthetic luteinizing hormone releasing hormone (LHRH) was studied in a female patient with Prader Willi syndrome and the response was compared with that obtained in prepubertal and pubertal subjects. LHRH caused the release of minimal amounts of LH and FSH in Prader Willi syndrome as compared with the LHRH response of prepubertal and pubertal female children. From these observations it is concluded that hypogonadotropism in Prader Willi syndrome may be due to a hypothalamic lesion associated with impaired or limited pituitary responsiveness.",

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author = "A. Z{\`a}rate and J. Soria and Canales, {E. S.} and Kastin, {A. J.} and Schally, {A. V.} and Toledano, {R. Guzm{\`a}n}",

year = "1973",

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doi = "10.1159/000122217",

language = "English (US)",

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AU - Zàrate, A.

AU - Soria, J.

AU - Canales, E. S.

AU - Kastin, A. J.

AU - Schally, A. V.

AU - Toledano, R. Guzmàn

PY - 1973/1/1

Y1 - 1973/1/1

N2 - Pituitary responsiveness to the intravenous injection of synthetic luteinizing hormone releasing hormone (LHRH) was studied in a female patient with Prader Willi syndrome and the response was compared with that obtained in prepubertal and pubertal subjects. LHRH caused the release of minimal amounts of LH and FSH in Prader Willi syndrome as compared with the LHRH response of prepubertal and pubertal female children. From these observations it is concluded that hypogonadotropism in Prader Willi syndrome may be due to a hypothalamic lesion associated with impaired or limited pituitary responsiveness.

AB - Pituitary responsiveness to the intravenous injection of synthetic luteinizing hormone releasing hormone (LHRH) was studied in a female patient with Prader Willi syndrome and the response was compared with that obtained in prepubertal and pubertal subjects. LHRH caused the release of minimal amounts of LH and FSH in Prader Willi syndrome as compared with the LHRH response of prepubertal and pubertal female children. From these observations it is concluded that hypogonadotropism in Prader Willi syndrome may be due to a hypothalamic lesion associated with impaired or limited pituitary responsiveness.

KW - LH-RH

KW - Pituitary

KW - Prader-willi syndrome

KW - Puberty

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Pituitary response to synthetic luteinizing hormone- releasing hormone in prader-willi syndrome, prepubertal and pubertal children

Abstract

Keywords

ASJC Scopus subject areas

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