Pituitary response to synthetic luteinizing hormone- releasing hormone in prader-willi syndrome, prepubertal and pubertal children

A. Zàrate, J. Soria, E. S. Canales, A. J. Kastin, A. V. Schally, R. Guzmàn Toledano

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Pituitary responsiveness to the intravenous injection of synthetic luteinizing hormone releasing hormone (LHRH) was studied in a female patient with Prader Willi syndrome and the response was compared with that obtained in prepubertal and pubertal subjects. LHRH caused the release of minimal amounts of LH and FSH in Prader Willi syndrome as compared with the LHRH response of prepubertal and pubertal female children. From these observations it is concluded that hypogonadotropism in Prader Willi syndrome may be due to a hypothalamic lesion associated with impaired or limited pituitary responsiveness.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalNeuroendocrinology
Volume13
Issue number6
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

Keywords

  • LH-RH
  • Pituitary
  • Prader-willi syndrome
  • Puberty

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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