Pituitary response to luteinizing hormone-releasing hormone analog at sea level and high altitudes

M. Paredes Suarez, J. R. Varea Teran, G. Garces, C. Avila, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two groups of subjects living at different altitudes were stimulated with synthetic luteinizing hormone-releasing hormone (LH-RH) or with an LH-RH analog. One hundred μg LH-RH was given subcutaneously to 19 men and 19 women, all normal, of reproductive age, and living at sea level, and to 19 men and 20 women living at a high altitude (2940 m). In neither sex, however, were the differences in peak responses for both gonadotropins significantly different between the sea level and high-altitude groups. Plasma levels of LH and follicle-stimulating hormone (FSH) were also measured after administration of [D-Leu6, des Gly-NH210]-LH-RH ethylamide (25 μg subcutaneously) in 32 men and 37 women living at sea level and at high altitude. The analog induced a powerful and protracted stimulation of the release of LH and FSH irrespective of altitude and sex. The responses of men and women to the LH-RH analog, both for LH as well as for FSH, were significantly greater at sea level than at high altitudes.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalObstetrics and Gynecology
Volume59
Issue number1
StatePublished - Mar 19 1982
Externally publishedYes

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Gonadotropin-Releasing Hormone
Oceans and Seas
Follicle Stimulating Hormone
Gonadotropins

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Paredes Suarez, M., Varea Teran, J. R., Garces, G., Avila, C., Coy, D. H., & Schally, A. V. (1982). Pituitary response to luteinizing hormone-releasing hormone analog at sea level and high altitudes. Obstetrics and Gynecology, 59(1), 52-57.

Pituitary response to luteinizing hormone-releasing hormone analog at sea level and high altitudes. / Paredes Suarez, M.; Varea Teran, J. R.; Garces, G.; Avila, C.; Coy, D. H.; Schally, Andrew V.

In: Obstetrics and Gynecology, Vol. 59, No. 1, 19.03.1982, p. 52-57.

Research output: Contribution to journalArticle

Paredes Suarez, M, Varea Teran, JR, Garces, G, Avila, C, Coy, DH & Schally, AV 1982, 'Pituitary response to luteinizing hormone-releasing hormone analog at sea level and high altitudes', Obstetrics and Gynecology, vol. 59, no. 1, pp. 52-57.
Paredes Suarez, M. ; Varea Teran, J. R. ; Garces, G. ; Avila, C. ; Coy, D. H. ; Schally, Andrew V. / Pituitary response to luteinizing hormone-releasing hormone analog at sea level and high altitudes. In: Obstetrics and Gynecology. 1982 ; Vol. 59, No. 1. pp. 52-57.
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