Pituitary pathology in acquired immunodeficiency syndrome

T. Sano, K. Kovacs, B. W. Scheithauer, M. K. Rosenblum, C. K. Petito, C. M. Greco

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Pituitary morphology was studied in 49 autopsied patients with acquired immunodeficiency syndrome. Direct infectious involvement was noted in six adenohypophyses (12%), including five cases by cytomegalovirus and one by Pneumocystis carinii. Two cases with neurohypophysial lesions presumable caused by cytomegalovirus and one questionable case of Toxoplasma gondii were also observed. In all instances these changes were associated with generalized and/or cerebral infection by these same agents. Neither Kaposi's sarcoma nor malignant lymphoma was encountered in the pituitary glands. Acute necrotic foci, presumably due to infarction, were noted in four cases. Four pituitary microadenomas (8%) and four hyperplastic nodules were identified. The incidence of such noninfectious lesions, as well as the prevalence and distribution of the various immunoreactive adenohypophysial cell types, were similar to those seen in the pituitary glands of age-matched male control patients.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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