6 women with isolated gonadotropin deficiency were stimulated with 50 μg of synthetic luteinizing hormone releasing hormone (LH RH) and their response was compared with that obtained from 10 eumenorrheic women. Patients with hypogonadotropic hypogonadism had low serum LH levels and normal or near normal concentrations of FSH. LH RH released relatively more LH in normal subjects than in hypogonadotropic patients; however FSH release, measured as maximal rise above baseline, did not differ significantly between normal patients and patients with isolated gonadotropin deficiency. It is concluded that in at least some women the isolated gonadotropin deficiency is probably due to a hypothalamic secretory defect associated with a partial failure of the LH secreting cells in the pituitary.
ASJC Scopus subject areas
- Obstetrics and Gynecology