Pituitary and Testicular Response to LH‐RH and to a Long‐Acting Analogue (D‐Leu‐6‐LH‐RH‐Ethylamide)

L. SCHWARZSTEIN, N. J. APARICIO, D. TURNER, E. A. de TURNER, A. V. SCHALLY, D. H. COY

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The LH, FSH and testosterone response to 50 μg i.v. LH-RH and to 2.5, 5.0, 10.0, and 20.0 μg i.m. D-Leu-6-LH-RH-ethylamide was studied in 6 subjects with normogonadotrophic, idiopathic oligozoospermia. All injections were given between 8:00 and 9:00 a.m. at weekly intervals. Blood samples were collected before and 30 and 45 minutes after injection of LH-RH, and before and 2, 4, 6, 12, and 24 hours after D-Leu-6-LH-RH-ethylamide injections. Serum levels of LH, FSH, and testosterone were measured by triplicate by R.I.A. LH and FSH responses to LH-RH showed peak values at 30 minutes, whereas following injections of D-Leu-6-LH-RH-ethylamide, maximal values were recorded between 4 and 6 hours and were higher than those obtained with LH-RH. A significant rise of serum testosterone levels was observed after all stimuli, with peak values 45 minutes after LH-RH and 4 to 6 hours after D-Leu-6-LH-RH-ethylamide injections. The testosterone levels obtained following LH-RH and different doses of the analogue did not differ significantly from one another. The same sequence of maximal LH and FSH values was obtained after injections of LH-RH and of D-Leu-6-LH-RH-ethylamide, particularly at doses of 10.0 and 20.0 μg. This suggests that the gonadotrophin response to these agents would be a true reflection of the individual mode of pituitary response.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalAndrologia
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Keywords

  • D‐Leu‐6‐LH‐RH‐ethylamide
  • FSH
  • LH
  • LH‐RH
  • oligozoospermia
  • testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Urology

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