TY - JOUR
T1 - Pituitary and Testicular Response to LH‐RH and to a Long‐Acting Analogue (D‐Leu‐6‐LH‐RH‐Ethylamide)
AU - SCHWARZSTEIN, L.
AU - APARICIO, N. J.
AU - TURNER, D.
AU - de TURNER, E. A.
AU - SCHALLY, A. V.
AU - COY, D. H.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - The LH, FSH and testosterone response to 50 μg i.v. LH-RH and to 2.5, 5.0, 10.0, and 20.0 μg i.m. D-Leu-6-LH-RH-ethylamide was studied in 6 subjects with normogonadotrophic, idiopathic oligozoospermia. All injections were given between 8:00 and 9:00 a.m. at weekly intervals. Blood samples were collected before and 30 and 45 minutes after injection of LH-RH, and before and 2, 4, 6, 12, and 24 hours after D-Leu-6-LH-RH-ethylamide injections. Serum levels of LH, FSH, and testosterone were measured by triplicate by R.I.A. LH and FSH responses to LH-RH showed peak values at 30 minutes, whereas following injections of D-Leu-6-LH-RH-ethylamide, maximal values were recorded between 4 and 6 hours and were higher than those obtained with LH-RH. A significant rise of serum testosterone levels was observed after all stimuli, with peak values 45 minutes after LH-RH and 4 to 6 hours after D-Leu-6-LH-RH-ethylamide injections. The testosterone levels obtained following LH-RH and different doses of the analogue did not differ significantly from one another. The same sequence of maximal LH and FSH values was obtained after injections of LH-RH and of D-Leu-6-LH-RH-ethylamide, particularly at doses of 10.0 and 20.0 μg. This suggests that the gonadotrophin response to these agents would be a true reflection of the individual mode of pituitary response.
AB - The LH, FSH and testosterone response to 50 μg i.v. LH-RH and to 2.5, 5.0, 10.0, and 20.0 μg i.m. D-Leu-6-LH-RH-ethylamide was studied in 6 subjects with normogonadotrophic, idiopathic oligozoospermia. All injections were given between 8:00 and 9:00 a.m. at weekly intervals. Blood samples were collected before and 30 and 45 minutes after injection of LH-RH, and before and 2, 4, 6, 12, and 24 hours after D-Leu-6-LH-RH-ethylamide injections. Serum levels of LH, FSH, and testosterone were measured by triplicate by R.I.A. LH and FSH responses to LH-RH showed peak values at 30 minutes, whereas following injections of D-Leu-6-LH-RH-ethylamide, maximal values were recorded between 4 and 6 hours and were higher than those obtained with LH-RH. A significant rise of serum testosterone levels was observed after all stimuli, with peak values 45 minutes after LH-RH and 4 to 6 hours after D-Leu-6-LH-RH-ethylamide injections. The testosterone levels obtained following LH-RH and different doses of the analogue did not differ significantly from one another. The same sequence of maximal LH and FSH values was obtained after injections of LH-RH and of D-Leu-6-LH-RH-ethylamide, particularly at doses of 10.0 and 20.0 μg. This suggests that the gonadotrophin response to these agents would be a true reflection of the individual mode of pituitary response.
KW - D‐Leu‐6‐LH‐RH‐ethylamide
KW - FSH
KW - LH
KW - LH‐RH
KW - oligozoospermia
KW - testosterone
UR - http://www.scopus.com/inward/record.url?scp=0017880314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017880314&partnerID=8YFLogxK
U2 - 10.1111/j.1439-0272.1978.tb01316.x
DO - 10.1111/j.1439-0272.1978.tb01316.x
M3 - Article
C2 - 343641
AN - SCOPUS:0017880314
VL - 10
SP - 59
EP - 65
JO - Andrologia
JF - Andrologia
SN - 0303-4569
IS - 1
ER -