Pituitary and Plasma Growth Hormone-Like Activity after Administration of Highly Purified Pig Growth Hormone-Releasing Factor

S. Sawano, A. Arimura, C. Y. Bowers, T. W. Redding, A. V. Schally

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effect of administration of highly purified pig GH-releasing factor (GRF) on the depletion of pituitary growth hormone (GH) content in recipient rats and levels of plasma GH-like activity were investigated using the tibia test method. It was demonstrated that GRF induced a significant increase in plasma GH-like activity which was accompanied by a simultaneous decrease in pituitary GH content. The levels of plasma GH-like activity in recipient rats treated with saline were not detectable (less than 1.25 μg/ml). These results seem to confirm that the “depletion” of pituitary GH content in rats caused by GRF indicates the “release” of GH.

Original languageEnglish (US)
Pages (from-to)1010-1014
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume127
Issue number4
DOIs
StatePublished - Apr 1968
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Pituitary and Plasma Growth Hormone-Like Activity after Administration of Highly Purified Pig Growth Hormone-Releasing Factor'. Together they form a unique fingerprint.

  • Cite this