Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy

Patrick J. Walsh, Clemence M. Veauvy, Danielle M Mcdonald, Matthew E. Pamenter, Leslie T. Buck, Michael P. Wilkie

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Although the number of fish species that have been studied for both hypoxia/anoxia tolerance and ammonia tolerance are few, there appears to be a correlation between the ability to survive these two insults. After establishing this correlation with examples from the literature, and after examining the role Peter Lutz played in catalyzing this convergent interest in two variables, this article explores potential mechanisms underpinning this correlation. We draw especially on the larger body of information for two human diseases with the same effected organ (brain), namely stroke and hepatic encephalopathy. While several dissimilarities exist between the responses of vertebrates to anoxia and hyperammonemia, one consistent observation in both conditions is an overactivation of NMDA receptors or glutamate neurotoxicity. We propose a glutamate excitotoxicity hypothesis to explain the correlation between ammonia and hypoxia resistance in fish. Furthermore, we suggest several experimental paths to test this hypothesis.

Original languageEnglish
Pages (from-to)332-343
Number of pages12
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume147
Issue number2 SPEC. ISS.
DOIs
StatePublished - Jun 1 2007

Fingerprint

Hepatic Encephalopathy
Ammonia
Fish
Toxicity
Glutamic Acid
Stroke
N-Methyl-D-Aspartate Receptors
Brain
Fishes
Hyperammonemia
Vertebrates
Observation
Hypoxia

Keywords

  • Ammonia
  • Anoxia
  • Fish models
  • Glutamate excitotoxicity
  • Glutamate neurotoxicity
  • Hyperammonemia
  • NMDA receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Physiology

Cite this

Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. / Walsh, Patrick J.; Veauvy, Clemence M.; Mcdonald, Danielle M; Pamenter, Matthew E.; Buck, Leslie T.; Wilkie, Michael P.

In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Vol. 147, No. 2 SPEC. ISS., 01.06.2007, p. 332-343.

Research output: Contribution to journalArticle

Walsh, Patrick J. ; Veauvy, Clemence M. ; Mcdonald, Danielle M ; Pamenter, Matthew E. ; Buck, Leslie T. ; Wilkie, Michael P. / Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 2007 ; Vol. 147, No. 2 SPEC. ISS. pp. 332-343.
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