Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats

Thomas H. Champney; Robert T. Matthews

doi:10.1111/j.1600-079X.1991.tb00473.x

Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats

Thomas H. Champney, Robert T. Matthews

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Administration of 3,4-methylenedioxymethamphetamine (MDMA) or para- chloroamphetamine (pCA) to adult rats is neurotoxic to serotonin (5HT) nerve terminals and cell bodies. MDMA (10 mg/kg) reduces 5HT levels in the frontal cortex, medial basal hypothalamus, and striatum acutely and 17 days after a series of multiple injections. The acute reductions occur within 1-2 hr after injection of doses greater than 3 mg/kg. A single injection of pCA reduces 5HT levels in the above mentioned brain regions as well as in the brain stem. However, none of these treatments are able to alter 5HT levels in the pineal gland. It appears that the pineal does not contain the 5HT reuptake system that is thought to be necessary for the neurotoxicity of MDMA and pCA.

Original language	English (US)
Pages (from-to)	163-167
Number of pages	5
Journal	Journal of Pineal Research
Volume	11
Issue number	3-4
DOIs	https://doi.org/10.1111/j.1600-079X.1991.tb00473.x
State	Published - Oct 1991
Externally published	Yes

Keywords

3,4‐methylene‐dioxymethamphetamine
para‐chloroamphetamine
pineal
rats
serotonin

ASJC Scopus subject areas

Endocrinology

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Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats

Abstract

Keywords

ASJC Scopus subject areas

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